Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma

Zhao Qing Shen; Yi Long Huang; Ting Fen Tsai

doi:10.1080/23723556.2018.1441627

Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma

Zhao Qing Shen, Yi Long Huang, Ting Fen Tsai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is the major risk factor leading to hepatocellular carcinoma (HCC). Cisd2 haploinsufficiency in mice causes NAFLD by disrupting Ca²⁺ homeostasis, indicating that CISD2 is a molecular target for the treatment of NAFLD and the prevention of HCC.

Original language	English
Article number	e1441627
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2018.1441627
State	Published - 4 May 2018

Keywords

calcium homeostasis
CISD2
ER stress
haploinsufficiency
hepatocellular carcinoma
nonalcoholic fatty liver disease
Serca2b
tumor suppressor gene

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2018.1441627

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@article{6d57223d76c3447ca385e300e8ae541c,

title = "Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma",

abstract = "Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is the major risk factor leading to hepatocellular carcinoma (HCC). Cisd2 haploinsufficiency in mice causes NAFLD by disrupting Ca2+ homeostasis, indicating that CISD2 is a molecular target for the treatment of NAFLD and the prevention of HCC.",

keywords = "calcium homeostasis, CISD2, ER stress, haploinsufficiency, hepatocellular carcinoma, nonalcoholic fatty liver disease, Serca2b, tumor suppressor gene",

author = "Shen, {Zhao Qing} and Huang, {Yi Long} and Tsai, {Ting Fen}",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2018, {\textcopyright} Zhao-Qing Shen, Yi-Long Huang and Ting-Fen Tsai.",

year = "2018",

month = may,

day = "4",

doi = "10.1080/23723556.2018.1441627",

language = "English",

volume = "5",

journal = "Molecular and Cellular Oncology",

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TY - JOUR

T1 - Cisd2 haploinsufficiency

T2 - A driving force for hepatocellular carcinoma

AU - Shen, Zhao Qing

AU - Huang, Yi Long

AU - Tsai, Ting Fen

PY - 2018/5/4

Y1 - 2018/5/4

N2 - Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is the major risk factor leading to hepatocellular carcinoma (HCC). Cisd2 haploinsufficiency in mice causes NAFLD by disrupting Ca2+ homeostasis, indicating that CISD2 is a molecular target for the treatment of NAFLD and the prevention of HCC.

AB - Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is the major risk factor leading to hepatocellular carcinoma (HCC). Cisd2 haploinsufficiency in mice causes NAFLD by disrupting Ca2+ homeostasis, indicating that CISD2 is a molecular target for the treatment of NAFLD and the prevention of HCC.

KW - calcium homeostasis

KW - CISD2

KW - ER stress

KW - haploinsufficiency

KW - hepatocellular carcinoma

KW - nonalcoholic fatty liver disease

KW - Serca2b

KW - tumor suppressor gene

UR - http://www.scopus.com/inward/record.url?scp=85050773643&partnerID=8YFLogxK

U2 - 10.1080/23723556.2018.1441627

DO - 10.1080/23723556.2018.1441627

M3 - Article

AN - SCOPUS:85050773643

SN - 2372-3556

VL - 5

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 3

M1 - e1441627

ER -

Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma

Abstract

Keywords

UN SDGs

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