Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma

Zhao Qing Shen, Yi Long Huang, Ting Fen Tsai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is the major risk factor leading to hepatocellular carcinoma (HCC). Cisd2 haploinsufficiency in mice causes NAFLD by disrupting Ca2+ homeostasis, indicating that CISD2 is a molecular target for the treatment of NAFLD and the prevention of HCC.

Original languageEnglish
Article numbere1441627
JournalMolecular and Cellular Oncology
Issue number3
StatePublished - 4 May 2018


  • calcium homeostasis
  • CISD2
  • ER stress
  • haploinsufficiency
  • hepatocellular carcinoma
  • nonalcoholic fatty liver disease
  • Serca2b
  • tumor suppressor gene


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