Circulating tumor cells as a “real-time liquid biopsy”: Recent advances and the application in ovarian cancer

Hei Jen Jou; Pei Ying Ling; Heng Tung Hsu

doi:10.1016/j.tjog.2021.11.008

Circulating tumor cells as a “real-time liquid biopsy”: Recent advances and the application in ovarian cancer

Hei Jen Jou^*, Pei Ying Ling, Heng Tung Hsu

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Even with the latest advances in technology, the treatment of ovarian cancer remains a big challenge because it is typically diagnosed at advanced stage, is prone to early relapse in spite of aggressive treatment and has an extremely poor prognosis. Circulating tumor cells (CTCs) can be used as a non-invasive “real-time liquid biopsy”, which has shown the value of diagnosis, assessment of prognosis and chemoresistance, and detection of small residual tumors on ovarian cancer. This review article provides an overview on recent research on CTCs in ovarian cancer, with special focus on the clinical application of CTC tests.

Original language	English
Journal	Taiwanese Journal of Obstetrics and Gynecology
DOIs	https://doi.org/10.1016/j.tjog.2021.11.008
State	Accepted/In press - 2021

Keywords

Circulating tumor cells
Liquid biopsy
Microfluidics
Ovarian cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tjog.2021.11.008

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title = "Circulating tumor cells as a “real-time liquid biopsy”: Recent advances and the application in ovarian cancer",

abstract = "Even with the latest advances in technology, the treatment of ovarian cancer remains a big challenge because it is typically diagnosed at advanced stage, is prone to early relapse in spite of aggressive treatment and has an extremely poor prognosis. Circulating tumor cells (CTCs) can be used as a non-invasive “real-time liquid biopsy”, which has shown the value of diagnosis, assessment of prognosis and chemoresistance, and detection of small residual tumors on ovarian cancer. This review article provides an overview on recent research on CTCs in ovarian cancer, with special focus on the clinical application of CTC tests.",

keywords = "Circulating tumor cells, Liquid biopsy, Microfluidics, Ovarian cancer",

author = "Jou, {Hei Jen} and Ling, {Pei Ying} and Hsu, {Heng Tung}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

doi = "10.1016/j.tjog.2021.11.008",

language = "English",

journal = "Taiwanese Journal of Obstetrics and Gynecology",

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TY - JOUR

T1 - Circulating tumor cells as a “real-time liquid biopsy”

T2 - Recent advances and the application in ovarian cancer

AU - Jou, Hei Jen

AU - Ling, Pei Ying

AU - Hsu, Heng Tung

PY - 2021

Y1 - 2021

N2 - Even with the latest advances in technology, the treatment of ovarian cancer remains a big challenge because it is typically diagnosed at advanced stage, is prone to early relapse in spite of aggressive treatment and has an extremely poor prognosis. Circulating tumor cells (CTCs) can be used as a non-invasive “real-time liquid biopsy”, which has shown the value of diagnosis, assessment of prognosis and chemoresistance, and detection of small residual tumors on ovarian cancer. This review article provides an overview on recent research on CTCs in ovarian cancer, with special focus on the clinical application of CTC tests.

AB - Even with the latest advances in technology, the treatment of ovarian cancer remains a big challenge because it is typically diagnosed at advanced stage, is prone to early relapse in spite of aggressive treatment and has an extremely poor prognosis. Circulating tumor cells (CTCs) can be used as a non-invasive “real-time liquid biopsy”, which has shown the value of diagnosis, assessment of prognosis and chemoresistance, and detection of small residual tumors on ovarian cancer. This review article provides an overview on recent research on CTCs in ovarian cancer, with special focus on the clinical application of CTC tests.

KW - Circulating tumor cells

KW - Liquid biopsy

KW - Microfluidics

KW - Ovarian cancer

UR - http://www.scopus.com/inward/record.url?scp=85120054208&partnerID=8YFLogxK

U2 - 10.1016/j.tjog.2021.11.008

DO - 10.1016/j.tjog.2021.11.008

M3 - Review article

C2 - 35181043

AN - SCOPUS:85120054208

SN - 1028-4559

JO - Taiwanese Journal of Obstetrics and Gynecology

JF - Taiwanese Journal of Obstetrics and Gynecology

ER -

Circulating tumor cells as a “real-time liquid biopsy”: Recent advances and the application in ovarian cancer

Abstract

Keywords

UN SDGs

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