Cigarette smoking and risk of herpes zoster: a population-based cohort study in Taiwan

Y. X. Dai; F. Y. Yeh; Y. J. Shen; Y. H. Tai; N. Huang; Y. T. Chang; Tzeng-Ji Chen; C. P. Li; C. Y. Wu

doi:10.1111/ced.14650

Cigarette smoking and risk of herpes zoster: a population-based cohort study in Taiwan

Y. X. Dai, F. Y. Yeh, Y. J. Shen, Y. H. Tai, N. Huang, Y. T. Chang, Tzeng-Ji Chen, C. P. Li, C. Y. Wu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The effects of cigarette smoking on the risk of herpes zoster (HZ) infection remain unclear. This study aimed to examine the association between cigarette smoking and HZ. Participants were collected from four rounds (2001, 2005, 2009 and 2013) of the Taiwan National Health Interview Survey. Incident cases of HZ were identified from the Taiwanese National Health Insurance database. Of the 57 641 participants, 3346 developed HZ during the observation period. After controlling for confounders, current smokers had a lower risk of incident HZ than never-smokers (adjusted hazard ratio 0.69; 95% CI 0.62–0.77). There was a trend toward a decreased risk of HZ with increasing numbers of cigarettes per day, years of smoking and cumulative pack-years of smoking among current smokers (P_trend < 0.001). Former smoking was not associated with risk of HZ. In conclusion, current smoking was significantly associated with a decreased risk of developing HZ.

Original language	English
Pages (from-to)	1293-1298
Number of pages	6
Journal	Clinical and Experimental Dermatology
Volume	46
Issue number	7
DOIs	https://doi.org/10.1111/ced.14650
State	Published - Oct 2021

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10.1111/ced.14650

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@article{1f187538a38445c59b218bd5412a50b9,

title = "Cigarette smoking and risk of herpes zoster: a population-based cohort study in Taiwan",

abstract = "The effects of cigarette smoking on the risk of herpes zoster (HZ) infection remain unclear. This study aimed to examine the association between cigarette smoking and HZ. Participants were collected from four rounds (2001, 2005, 2009 and 2013) of the Taiwan National Health Interview Survey. Incident cases of HZ were identified from the Taiwanese National Health Insurance database. Of the 57 641 participants, 3346 developed HZ during the observation period. After controlling for confounders, current smokers had a lower risk of incident HZ than never-smokers (adjusted hazard ratio 0.69; 95% CI 0.62–0.77). There was a trend toward a decreased risk of HZ with increasing numbers of cigarettes per day, years of smoking and cumulative pack-years of smoking among current smokers (Ptrend < 0.001). Former smoking was not associated with risk of HZ. In conclusion, current smoking was significantly associated with a decreased risk of developing HZ.",

author = "Dai, {Y. X.} and Yeh, {F. Y.} and Shen, {Y. J.} and Tai, {Y. H.} and N. Huang and Chang, {Y. T.} and Tzeng-Ji Chen and Li, {C. P.} and Wu, {C. Y.}",

note = "Publisher Copyright: {\textcopyright} 2021 British Association of Dermatologists.",

year = "2021",

month = oct,

doi = "10.1111/ced.14650",

language = "English",

volume = "46",

pages = "1293--1298",

journal = "Clinical and Experimental Dermatology",

issn = "0307-6938",

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TY - JOUR

T1 - Cigarette smoking and risk of herpes zoster

T2 - a population-based cohort study in Taiwan

AU - Dai, Y. X.

AU - Yeh, F. Y.

AU - Shen, Y. J.

AU - Tai, Y. H.

AU - Huang, N.

AU - Chang, Y. T.

AU - Chen, Tzeng-Ji

AU - Li, C. P.

AU - Wu, C. Y.

PY - 2021/10

Y1 - 2021/10

N2 - The effects of cigarette smoking on the risk of herpes zoster (HZ) infection remain unclear. This study aimed to examine the association between cigarette smoking and HZ. Participants were collected from four rounds (2001, 2005, 2009 and 2013) of the Taiwan National Health Interview Survey. Incident cases of HZ were identified from the Taiwanese National Health Insurance database. Of the 57 641 participants, 3346 developed HZ during the observation period. After controlling for confounders, current smokers had a lower risk of incident HZ than never-smokers (adjusted hazard ratio 0.69; 95% CI 0.62–0.77). There was a trend toward a decreased risk of HZ with increasing numbers of cigarettes per day, years of smoking and cumulative pack-years of smoking among current smokers (Ptrend < 0.001). Former smoking was not associated with risk of HZ. In conclusion, current smoking was significantly associated with a decreased risk of developing HZ.

AB - The effects of cigarette smoking on the risk of herpes zoster (HZ) infection remain unclear. This study aimed to examine the association between cigarette smoking and HZ. Participants were collected from four rounds (2001, 2005, 2009 and 2013) of the Taiwan National Health Interview Survey. Incident cases of HZ were identified from the Taiwanese National Health Insurance database. Of the 57 641 participants, 3346 developed HZ during the observation period. After controlling for confounders, current smokers had a lower risk of incident HZ than never-smokers (adjusted hazard ratio 0.69; 95% CI 0.62–0.77). There was a trend toward a decreased risk of HZ with increasing numbers of cigarettes per day, years of smoking and cumulative pack-years of smoking among current smokers (Ptrend < 0.001). Former smoking was not associated with risk of HZ. In conclusion, current smoking was significantly associated with a decreased risk of developing HZ.

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U2 - 10.1111/ced.14650

DO - 10.1111/ced.14650

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C2 - 33763912

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SN - 0307-6938

VL - 46

SP - 1293

EP - 1298

JO - Clinical and Experimental Dermatology

JF - Clinical and Experimental Dermatology

IS - 7

ER -

Cigarette smoking and risk of herpes zoster: a population-based cohort study in Taiwan

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