cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck

Chi Long Chen; Chun Yi Chiang; Kuang-Wen Liao; Shu Yi Ho; Yi Fang Chang; Ken Hong Lim; Ruey Kuen Hsieh; Yu Ling Lin; Ying Wen Su

doi:10.1016/j.ijge.2016.04.003

cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck

Chi Long Chen, Chun Yi Chiang, Kuang-Wen Liao, Shu Yi Ho, Yi Fang Chang, Ken Hong Lim, Ruey Kuen Hsieh, Yu Ling Lin, Ying Wen Su^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0–3) and statistical association with clinical–pathological factors was determined. Results High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical–pathologic factors.

Original language	English
Pages (from-to)	22-26
Number of pages	5
Journal	International Journal of Gerontology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/j.ijge.2016.04.003
State	Published - 1 Mar 2017

Keywords

cIAP-2
squamous cell carcinoma of head and neck

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@article{ed3c82182f754c589433037bbffae769,

title = "cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck",

abstract = "Background Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0–3) and statistical association with clinical–pathological factors was determined. Results High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical–pathologic factors.",

keywords = "cIAP-2, squamous cell carcinoma of head and neck",

author = "Chen, {Chi Long} and Chiang, {Chun Yi} and Kuang-Wen Liao and Ho, {Shu Yi} and Chang, {Yi Fang} and Lim, {Ken Hong} and Hsieh, {Ruey Kuen} and Lin, {Yu Ling} and Su, {Ying Wen}",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = mar,

day = "1",

doi = "10.1016/j.ijge.2016.04.003",

language = "English",

volume = "11",

pages = "22--26",

journal = "International Journal of Gerontology",

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publisher = "Elsevier Taiwan LLC",

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TY - JOUR

T1 - cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck

AU - Chen, Chi Long

AU - Chiang, Chun Yi

AU - Liao, Kuang-Wen

AU - Ho, Shu Yi

AU - Chang, Yi Fang

AU - Lim, Ken Hong

AU - Hsieh, Ruey Kuen

AU - Lin, Yu Ling

AU - Su, Ying Wen

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0–3) and statistical association with clinical–pathological factors was determined. Results High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical–pathologic factors.

AB - Background Evidence indicates apoptosis deregulation is associated with aging. We correlated expression of cIAP-2, a member of the inhibitor of apoptosis protein family, with survival and age in patients with resected squamous cell carcinoma of head and neck (SCCHN). Methods Immunohistochemical (IHC) staining for cIAP-2 and other markers were performed using tissue microarrays from 103 resected SCCHN patients. Expression was grouped according to IHC scores (0–3) and statistical association with clinical–pathological factors was determined. Results High expression of cIAP-2 was found to be increased in patients aged 60 or greater. High expression of cIAP-2 and an age ≥60 were significantly associated with worse survival in univariate analysis, but only an age ≥60, and not cIAP-2 expression, was prognostic in multivariate analysis. Conclusion High expression of cIAP-2 was found more frequently in elderly SCCHN patients but was not independently associated with survival after adjusting other clinical–pathologic factors.

KW - cIAP-2

KW - squamous cell carcinoma of head and neck

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DO - 10.1016/j.ijge.2016.04.003

M3 - Article

AN - SCOPUS:85009200660

SN - 1873-9598

VL - 11

SP - 22

EP - 26

JO - International Journal of Gerontology

JF - International Journal of Gerontology

IS - 1

ER -

cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck

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