Chronic obstructive pulmonary disease is associated with increased recurrent peptic ulcer bleeding risk

Kuang Wei Huang, Yi Chun Kuan, Nai Fang Chi, Yao Hsien Huang, Jiing Chyuan Luo, Li Nien Chien*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background The association between chronic obstructive pulmonary disease (COPD) and the risk of recurrent peptic ulcer bleeding (PUB) remains unclear. In this study, we compared the risk of recurrent PUB between patients with and those without COPD. Methods Using the Taiwan National Health Insurance Research Database, we first selected patients newly diagnosed with PUB in 2002–2009. Two groups comprising 13,732 COPD cases and 13,732 non-COPD matched controls were created using propensity score matching, thereby making the differences in basic demographics, medication use, and disease conditions between the two groups negligible. Cox proportional hazard regression was used to evaluate the risk of recurrent PUB during the follow-up period. Results The cumulative recurrence rate of PUB was significantly higher in the patients with COPD than in the non-COPD matched controls (2 years: 10.8% vs 9.3%; 6 years: 18.3% vs 15.7%, P all < 0.05), with an adjusted hazard ratio (HR) of 1.17 (95% confidence interval [CI], 1.08–1.26, P < 0.001) and 1.19 (95% CI, 1.12–1.26, P < 0.001) within 2-year and 6-year follow-ups, respectively. Patients with COPD using steroids were at a marginally higher risk of recurrent PUB than those who did not use steroids. Multivariate stratified analysis revealed similar results in many subgroups. Conclusions The risk of recurrent PUB is higher in patients with COPD than in patients without COPD.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalEuropean Journal of Internal Medicine
StatePublished - 1 Jan 2017


  • Chronic obstructive pulmonary disease (COPD)
  • Recurrent peptic ulcer bleeding (PUB)
  • Steroids


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