Chromosomal analysis of hepatic adenoma and focal nodular hyperplasia by comparative genomic hybridization

Yann Jang Chen, Pei Jer Chen, Mei Chi Lee, Shiou Hwei Yeh, Ming Ta Hsu, Chi Hung Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Hepatic adenoma (HA) and focal nodular hyperplasia (FNH) are two common non-malignant tumors of the liver. Genomic analysis on these benign lesions may shed light on the genetic mechanism underlying liver carcinogenesis. We used comparative genomic hybridization (CGH) to evaluate genomic changes in eight cases of HA and six cases of FNH, obtained by surgical procedures; the resulting chromosomal aberration profiles were analyzed together with their pathological and clinical manifestations. We found consistent chromosomal lesions associated with both non-malignant hepatic tumors. The overall genomic abnormalities in HA and FNH were much less obvious than those in hepatocellular carcinoma (HCC). Among these limited changes, frequent gains were located on chromosomal arms 1q (50%), 17q (50%), 1p (38%), and 11q (38%) in HA, and on 11q (50%), 9q (33%), 17q (33%), and 22q (33%) in FNH. Gains outnumbered losses, and HA contained more CGH abnormalities than did FNH. Interestingly, CGH alteration hotspots found in HA, but not in FNH, appeared largely to coincide with common genomic lesions of cancerous HCC, suggesting an interesting relationship along the tumorigenesis pathway of HA and HCC.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalGenes Chromosomes and Cancer
Issue number2
StatePublished - Oct 2002


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