Chemical and biological assessments of environmental mixtures: A review of current trends, advances, and future perspectives

Yu Syuan Luo*, Zunwei Chen, Nan Hung Hsieh, Tzu En Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Considering the chemical complexity and toxicity data gaps of environmental mixtures, most studies evaluate the chemical risk individually. However, humans are usually exposed to a cocktail of chemicals in real life. Mixture health assessment remains to be a research area having significant knowledge gaps. Characterization of chemical composition and bioactivity/toxicity are the two critical aspects of mixture health assessments. This review seeks to introduce the recent progress and tools for the chemical and biological characterization of environmental mixtures. The state-of-the-art techniques include the sampling, extraction, rapid detection methods, and the in vitro, in vivo, and in silico approaches to generate the toxicity data of an environmental mixture. Application of these novel methods, or new approach methodologies (NAMs), has increased the throughput of generating chemical and toxicity data for mixtures and thus refined the mixture health assessment. Combined with computational methods, the chemical and biological information would shed light on identifying the bioactive/toxic components in an environmental mixture.

Original languageEnglish
Article number128658
JournalJournal of Hazardous Materials
Volume432
DOIs
StatePublished - 15 Jun 2022

Keywords

  • Cell-based models
  • Chemical characterization
  • Environmental mixture
  • Mixture modeling
  • New approach methodology
  • Toxicity

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