Abstract
A novel paired surface plasma wave biosensor (PSPWB) is described and setup. By integrating the features of a common-path optical heterodyne interferometer and the amplitude-ratio detection mode, the PSPWB not only produces a high detection sensitivity but also provides a large dynamic measurement range for effective refractive index (Δneff) based on amplitude-sensitive detection method. Thus, the performance of PSPWB becomes equivalent to shot-noise limited of a conventional SPR biosensor. To our knowledge, this novel PSPWB shows the highest detection sensitivity on Δneff when compared with conventional SPR biosensors using either a non-interferometric or interferometric technique. The experimental results correctly verify the properties of a PSPWB that the detection sensitivity is an order of 10-7 refractive index unit (RIU) when measuring a 0.001% sucrose-water solution. This result confirms the detection sensitivity up to 10-9 RIU of the IgG/anti-IgG interaction in real time successfully. Furthermore, a dynamic range of 105 using PSPWB was also obtained.
Original language | English |
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Pages (from-to) | 4307-4315 |
Number of pages | 9 |
Journal | Optics Express |
Volume | 14 |
Issue number | 10 |
DOIs | |
State | Published - May 2006 |