Chapter 2 Viral Channel-Forming Proteins

Wolfgang B. Fischer*, Jens Krüger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Channel-forming proteins are found in a number of viral genomes. In some cases, their role in the viral life cycle is well understood, in some cases it needs still to be elucidated. A common theme is that their mode of action involves a change of electrochemical or proton gradient across the lipid membrane which modulates the viral or cellular activity. Blocking these proteins can be a suitable therapeutic strategy as for some viruses this may be "lethal." Besides the many biological relevant questions still to be answered, there are also many open questions concerning the biophysical side as well as structural information and the mechanism of function on a molecular level. The immanent biophysical issues are addressed and the work in the field is summarized.

Original languageEnglish
Pages (from-to)35-63
Number of pages29
JournalInternational Review of Cell and Molecular Biology
Issue numberC
StatePublished - 2009


  • Antiviral therapy
  • Protein assembly
  • Viral channel proteins
  • Viruses


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