TY - JOUR
T1 - Changes in functional connectivity of pain modulatory systems in women with primary dysmenorrhea
AU - Wei, Shyh Yuh
AU - Chao, Hsiang Tai
AU - Tu, Cheng Hao
AU - Li, Wei Chi
AU - Low, Intan
AU - Chuang, Chih Ying
AU - Chen, Li Fen
AU - Hsieh, Jen Chuen
N1 - Publisher Copyright:
© 2015 International Association for the Study of Pain.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Menstrual pain is the most prevalent gynecological complaint, and is usually without organic cause (termed primary dysmenorrhea, PDM). The high comorbidity in the later life of PDM with many functional pain disorders (associated with central dysfunction of pain inhibition, eg, fibromyalgia) suggests possible maladaptive functionality of pain modulatory systems already occurred in young PDM women, making them vulnerable to functional pain disorders. Periaqueductal gray (PAG) matter functions as a critical hub in the neuraxis of pain modulatory systems; therefore, we investigated the functional connectivity of PAG in PDM. Forty-six PDM subjects and 49 controls received resting-state functional magnetic resonance imaging during menstruation and periovulatory phases. The PAG of PDM subjects exhibited adaptive/reactive hyperconnectivity with the sensorimotor cortex during painful menstruation, whereas it exhibited maladaptive hypoconnectivity with the dorsolateral prefrontal cortex and default mode network (involving the ventromedial prefrontal cortex, posterior cingulate cortex, or posterior parietal cortex) during menstruation or periovulatory phase. We propose that the maladaptive descending pain modulatory systems in PDM may underpin the central susceptibility to subsequent development of various functional disorders later in life. This hypothesis is corroborated by the growing body of evidence that hypoconnectivity between PAG and default mode network is a coterminal to many functional pain disorders.
AB - Menstrual pain is the most prevalent gynecological complaint, and is usually without organic cause (termed primary dysmenorrhea, PDM). The high comorbidity in the later life of PDM with many functional pain disorders (associated with central dysfunction of pain inhibition, eg, fibromyalgia) suggests possible maladaptive functionality of pain modulatory systems already occurred in young PDM women, making them vulnerable to functional pain disorders. Periaqueductal gray (PAG) matter functions as a critical hub in the neuraxis of pain modulatory systems; therefore, we investigated the functional connectivity of PAG in PDM. Forty-six PDM subjects and 49 controls received resting-state functional magnetic resonance imaging during menstruation and periovulatory phases. The PAG of PDM subjects exhibited adaptive/reactive hyperconnectivity with the sensorimotor cortex during painful menstruation, whereas it exhibited maladaptive hypoconnectivity with the dorsolateral prefrontal cortex and default mode network (involving the ventromedial prefrontal cortex, posterior cingulate cortex, or posterior parietal cortex) during menstruation or periovulatory phase. We propose that the maladaptive descending pain modulatory systems in PDM may underpin the central susceptibility to subsequent development of various functional disorders later in life. This hypothesis is corroborated by the growing body of evidence that hypoconnectivity between PAG and default mode network is a coterminal to many functional pain disorders.
KW - Default mode network
KW - Functional connectivity
KW - Magnetic resonance imaging
KW - Pain modulatory systems
KW - Periaqueductal gray
UR - http://www.scopus.com/inward/record.url?scp=84953744107&partnerID=8YFLogxK
U2 - 10.1097/j.pain.0000000000000340
DO - 10.1097/j.pain.0000000000000340
M3 - Article
C2 - 26307856
AN - SCOPUS:84953744107
SN - 0304-3959
VL - 157
SP - 92
EP - 102
JO - Pain
JF - Pain
IS - 1
ER -