Cefepime-related encephalopathy in peritoneal dialysis patients

Chun Jen Lin, Shih Pin Chen, Shuu Jiun Wang, Jong Ling Fuh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Encephalopathy or neurotoxicity can occur with cefepime use in patients with impaired or relatively normal renal function. However, few articles have examined the relationship between cefepime's adverse effects and peritoneal dialysis.Here, we report the case of an 80-year-old woman with chronic renal failure on peritoneal dialysis that developed agitation, confusion, and dystonia after cefepime administration for 2 days. The clinical and electroencephalographic abnormalities improved after discontinuation the drug. We review the role of peritoneal dialysis in the development of cefepime-induced encephalopathy. Peritoneal dialysis is a less efficient way to eliminate cefepime than hemodialysis. Short-term hemodialysis might be considered to facilitate elimination of the drug in patients who have developed neurotoxicity.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalJournal of the Chinese Medical Association
Issue number2
StatePublished - Feb 2011


  • Cefepime
  • Electroencephalogram
  • Encephalopathy
  • Peritoneal dialysis


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