CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease

Ting Ting Chang*, Ching Chen, Jaw Wen Chen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Chemokines are key components in the pathology of chronic diseases. Chemokine CC motif ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus, and kidney disease. CCL7 may play a role in inflammatory events by attracting macrophages and monocytes to further amplify inflammatory processes and contribute to disease progression. However, CCL7-specific pathological signaling pathways need to be further confirmed in these chronic diseases. Given the multiple redundancy system among chemokines and their receptors, further experimental and clinical studies are needed to clarify whether direct CCL7 inhibition mechanisms could be a promising therapeutic approach to attenuating the development of cardiovascular disease, diabetes mellitus, and kidney disease.

Original languageEnglish
Article number185
JournalCardiovascular Diabetology
Volume21
Issue number1
DOIs
StatePublished - Dec 2022

Keywords

  • Cardiovascular disease
  • Chemokine
  • Chemokine CC motif ligand 7
  • Chronic kidney disease
  • Diabetes mellitus
  • Diabetic kidney disease

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