TY - JOUR
T1 - Cardiovascular risks and brain function
T2 - A functional magnetic resonance imaging study of executive function in older adults
AU - Chuang, Yi Fang
AU - Eldreth, Dana
AU - Erickson, Kirk I.
AU - Varma, Vijay
AU - Harris, Gregory
AU - Fried, Linda P.
AU - Rebok, George W.
AU - Tanner, Elizabeth K.
AU - Carlson, Michelle C.
N1 - Funding Information:
The authors thank study participants for their contribution to the study. This work was supported by the National Institute on Aging (BSR grant P01 AG027735-03 ), the National Institute on Aging Claude D. Pepper Older Americans Independence Center ( P30 AG021334 ), the Alzheimer's Drug Discovery Foundation , S.B. Bechtel Grant , and the Johns Hopkins Neurobehavioral Research Unit .
PY - 2014/6
Y1 - 2014/6
N2 - Cardiovascular (CV) risk factors, such as hypertension, diabetes, and hyperlipidemia are associated with cognitive impairment and risk of dementia in older adults. However, the mechanisms linking them are not clear. This study aims to investigate the association between aggregate CV risk, assessed by the Framingham general cardiovascular risk profile, and functional brain activation in a group of community-dwelling older adults. Sixty participants (mean age: 64.6years) from the Brain Health Study, a nested study of the Baltimore Experience Corps Trial, underwent functional magnetic resonance imaging using the Flanker task. We found that participants with higher CV risk had greater task-related activation in the left inferior parietal region, and this increased activation was associated with poorer task performance. Our results provide insights into the neural systems underlying the relationship between CV risk and executive function. Increased activation of the inferior parietal region may offer a pathway through which CV risk increases risk for cognitive impairment.
AB - Cardiovascular (CV) risk factors, such as hypertension, diabetes, and hyperlipidemia are associated with cognitive impairment and risk of dementia in older adults. However, the mechanisms linking them are not clear. This study aims to investigate the association between aggregate CV risk, assessed by the Framingham general cardiovascular risk profile, and functional brain activation in a group of community-dwelling older adults. Sixty participants (mean age: 64.6years) from the Brain Health Study, a nested study of the Baltimore Experience Corps Trial, underwent functional magnetic resonance imaging using the Flanker task. We found that participants with higher CV risk had greater task-related activation in the left inferior parietal region, and this increased activation was associated with poorer task performance. Our results provide insights into the neural systems underlying the relationship between CV risk and executive function. Increased activation of the inferior parietal region may offer a pathway through which CV risk increases risk for cognitive impairment.
KW - Brain function
KW - Cardiovascular risk
KW - Executive function
KW - FMRI
KW - Framingham risk score
KW - Older adults
UR - http://www.scopus.com/inward/record.url?scp=84903368601&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2013.12.008
DO - 10.1016/j.neurobiolaging.2013.12.008
M3 - Article
C2 - 24439485
AN - SCOPUS:84903368601
SN - 0197-4580
VL - 35
SP - 1396
EP - 1403
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 6
ER -
