Cardiac repair using chitosan-hyaluronan/silk fibroin patches in a rat heart model with myocardial infarction

Nai Hsin Chi; Ming Chia Yang; Tze Wen Chung; Nai Kuan Chou; Shoei Shen Wang

doi:10.1016/j.carbpol.2012.09.012

Cardiac repair using chitosan-hyaluronan/silk fibroin patches in a rat heart model with myocardial infarction

Nai Hsin Chi, Ming Chia Yang, Tze Wen Chung^*, Nai Kuan Chou, Shoei Shen Wang

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

The cardiac repair of myocardial infarction (MI) hearts of rats using chitosan-hyaluronan/silk fibroin (chitosan-HYA/SF) cardiac patches was examined after eight weeks of implantation. Rats with implantations of chitosan-HYA/SF patches (CHS group) significantly (P < 0.05) reduced the dilation of the inner diameter of left ventricle (LV) (4.27 ± 0.29 mm), increased wall thickness of LV (1.5 ± 0.13 mm) and improved the fractional shortening of LV of hearts (LVFS) (42.8 ± 2.4%) compared with those values of LVs of rats without implants (MI group) (e.g.; 5.92 ± 0.39 mm, 1.2 ± 0.06 mm and 31.5 ± 1.4%, respectively). Moreover, blood vessel-like structures in MI regions of LVs in the CHS group were widely distributed while none was found in the MI group. The CHS group significantly improved the secretion of paracrine factors, such as VEGF in the MI regions of LVs (P < 0.05, n = 4), relative to that in the MI group. In conclusion, chitosan-HYA/SF cardiac patches are promising biomaterials for the cardiac repair of MI rat hearts.

Original language	English
Pages (from-to)	591-597
Number of pages	7
Journal	Carbohydrate Polymers
Volume	92
Issue number	1
DOIs	https://doi.org/10.1016/j.carbpol.2012.09.012
State	Published - 30 Jan 2013

Keywords

Angiogenesis
Cardiac repair
Chitosan-HYA/SF cardiac patch
Myocardial infarction
Paracrine factors

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10.1016/j.carbpol.2012.09.012

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title = "Cardiac repair using chitosan-hyaluronan/silk fibroin patches in a rat heart model with myocardial infarction",

abstract = "The cardiac repair of myocardial infarction (MI) hearts of rats using chitosan-hyaluronan/silk fibroin (chitosan-HYA/SF) cardiac patches was examined after eight weeks of implantation. Rats with implantations of chitosan-HYA/SF patches (CHS group) significantly (P < 0.05) reduced the dilation of the inner diameter of left ventricle (LV) (4.27 ± 0.29 mm), increased wall thickness of LV (1.5 ± 0.13 mm) and improved the fractional shortening of LV of hearts (LVFS) (42.8 ± 2.4%) compared with those values of LVs of rats without implants (MI group) (e.g.; 5.92 ± 0.39 mm, 1.2 ± 0.06 mm and 31.5 ± 1.4%, respectively). Moreover, blood vessel-like structures in MI regions of LVs in the CHS group were widely distributed while none was found in the MI group. The CHS group significantly improved the secretion of paracrine factors, such as VEGF in the MI regions of LVs (P < 0.05, n = 4), relative to that in the MI group. In conclusion, chitosan-HYA/SF cardiac patches are promising biomaterials for the cardiac repair of MI rat hearts.",

keywords = "Angiogenesis, Cardiac repair, Chitosan-HYA/SF cardiac patch, Myocardial infarction, Paracrine factors",

author = "Chi, {Nai Hsin} and Yang, {Ming Chia} and Chung, {Tze Wen} and Chou, {Nai Kuan} and Wang, {Shoei Shen}",

note = "Funding Information: The authors would like to thank the National Science Council of the Republic of China, Taiwan , for financially supporting this research under Contract Nos. NSC-100-2221-E-224-007 and 100-2314-B-002-047. Ted Knoy is appreciated for his editorial assistance.",

year = "2013",

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doi = "10.1016/j.carbpol.2012.09.012",

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T1 - Cardiac repair using chitosan-hyaluronan/silk fibroin patches in a rat heart model with myocardial infarction

AU - Chi, Nai Hsin

AU - Yang, Ming Chia

AU - Chung, Tze Wen

AU - Chou, Nai Kuan

AU - Wang, Shoei Shen

N1 - Funding Information: The authors would like to thank the National Science Council of the Republic of China, Taiwan , for financially supporting this research under Contract Nos. NSC-100-2221-E-224-007 and 100-2314-B-002-047. Ted Knoy is appreciated for his editorial assistance.

PY - 2013/1/30

Y1 - 2013/1/30

N2 - The cardiac repair of myocardial infarction (MI) hearts of rats using chitosan-hyaluronan/silk fibroin (chitosan-HYA/SF) cardiac patches was examined after eight weeks of implantation. Rats with implantations of chitosan-HYA/SF patches (CHS group) significantly (P < 0.05) reduced the dilation of the inner diameter of left ventricle (LV) (4.27 ± 0.29 mm), increased wall thickness of LV (1.5 ± 0.13 mm) and improved the fractional shortening of LV of hearts (LVFS) (42.8 ± 2.4%) compared with those values of LVs of rats without implants (MI group) (e.g.; 5.92 ± 0.39 mm, 1.2 ± 0.06 mm and 31.5 ± 1.4%, respectively). Moreover, blood vessel-like structures in MI regions of LVs in the CHS group were widely distributed while none was found in the MI group. The CHS group significantly improved the secretion of paracrine factors, such as VEGF in the MI regions of LVs (P < 0.05, n = 4), relative to that in the MI group. In conclusion, chitosan-HYA/SF cardiac patches are promising biomaterials for the cardiac repair of MI rat hearts.

AB - The cardiac repair of myocardial infarction (MI) hearts of rats using chitosan-hyaluronan/silk fibroin (chitosan-HYA/SF) cardiac patches was examined after eight weeks of implantation. Rats with implantations of chitosan-HYA/SF patches (CHS group) significantly (P < 0.05) reduced the dilation of the inner diameter of left ventricle (LV) (4.27 ± 0.29 mm), increased wall thickness of LV (1.5 ± 0.13 mm) and improved the fractional shortening of LV of hearts (LVFS) (42.8 ± 2.4%) compared with those values of LVs of rats without implants (MI group) (e.g.; 5.92 ± 0.39 mm, 1.2 ± 0.06 mm and 31.5 ± 1.4%, respectively). Moreover, blood vessel-like structures in MI regions of LVs in the CHS group were widely distributed while none was found in the MI group. The CHS group significantly improved the secretion of paracrine factors, such as VEGF in the MI regions of LVs (P < 0.05, n = 4), relative to that in the MI group. In conclusion, chitosan-HYA/SF cardiac patches are promising biomaterials for the cardiac repair of MI rat hearts.

KW - Angiogenesis

KW - Cardiac repair

KW - Chitosan-HYA/SF cardiac patch

KW - Myocardial infarction

KW - Paracrine factors

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JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

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ER -

Cardiac repair using chitosan-hyaluronan/silk fibroin patches in a rat heart model with myocardial infarction

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