Carbonylative Mizoroki-Heck Reaction of Alkyl Iodides with Arylalkenes Using a Pd/Photoirradiation System

Shuhei Sumino, Takahito Ui, Yuki Hamada, Takahide Fukuyama, Ilhyong Ryu*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    34 Scopus citations

    Abstract

    A carbonylative Mizoroki-Heck reaction using alkyl iodides was achieved with a Pd/photoirradiation system using DBU as a base. In this reaction, alkyl radicals were formed from alkyl iodides via single-electron transfer (SET) and then underwent a sequential addition to CO and alkenes to give β-keto radicals. It is proposed that DBU would abstract a proton α to carbonyl to form radical anions, giving α,β-unsaturated ketones via SET.

    Original languageEnglish
    Pages (from-to)4952-4955
    Number of pages4
    JournalOrganic Letters
    Volume17
    Issue number20
    DOIs
    StatePublished - 16 Oct 2015

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