TY - JOUR
T1 - Cancellation but not restraint ability is modulated by trait anxiety
T2 - An event-related potential and oscillation study using Go-Nogo and stop-signal tasks
AU - Hsieh, Meng Tien
AU - Lu, Hsinjie
AU - Chen, Li Fen
AU - Liu, Chia Yih
AU - Hsu, Shih Chieh
AU - Cheng, Chia Hsiung
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2022/2/15
Y1 - 2022/2/15
N2 - Background: Trait anxiety has a detrimental effect on attention, which further leads to dysfunction of inhibitory control. However, there is no study examining how trait anxiety modulates inhibitory abilities on restraint and cancellation in the same subjects. Therefore, we aimed to use electrophysiological recordings to interrogate whether and to what extent trait anxiety modulated these two kinds of inhibitory functions. The Cognitive Failures Questionnaire (CFQ), a self-reported assessment of daily absentmindedness, was also used to examine its association with inhibition-related electrophysiological indicators. Methods: Forty subjects were recruited from the top 10% (Higher Trait Anxiety [HTA], n= 20) and last 10% (Lower Trait Anxiety [LTA], n= 20) of the trait anxiety score distribution from 400 college students. During electrophysiological recordings, the Go-Nogo and stop-signal tasks were performed, which evaluated the abilities of restraint and cancellation, respectively. Results: The HTA and LTA groups showed a comparable behavioral performance of restraint and cancellation abilities. However, the results of time–frequency analysis revealed that those with HTA demonstrated a stronger power of alpha oscillations (600‒1000 ms) in response to Stop trials in the stop-signal task, compared with individuals with LTA. Such oscillatory activity was positively correlated with the CFQ score. There was no significant between-group difference of the brain activation in the Go-Nogo task. Limitations: Future studies can recruit both individuals with trait anxiety and anxiety disorders to clarify the boundaries between healthy and pathological worries in terms of cancellation ability. Conclusions: cancellation, but not restraint, is modulated by trait anxiety.
AB - Background: Trait anxiety has a detrimental effect on attention, which further leads to dysfunction of inhibitory control. However, there is no study examining how trait anxiety modulates inhibitory abilities on restraint and cancellation in the same subjects. Therefore, we aimed to use electrophysiological recordings to interrogate whether and to what extent trait anxiety modulated these two kinds of inhibitory functions. The Cognitive Failures Questionnaire (CFQ), a self-reported assessment of daily absentmindedness, was also used to examine its association with inhibition-related electrophysiological indicators. Methods: Forty subjects were recruited from the top 10% (Higher Trait Anxiety [HTA], n= 20) and last 10% (Lower Trait Anxiety [LTA], n= 20) of the trait anxiety score distribution from 400 college students. During electrophysiological recordings, the Go-Nogo and stop-signal tasks were performed, which evaluated the abilities of restraint and cancellation, respectively. Results: The HTA and LTA groups showed a comparable behavioral performance of restraint and cancellation abilities. However, the results of time–frequency analysis revealed that those with HTA demonstrated a stronger power of alpha oscillations (600‒1000 ms) in response to Stop trials in the stop-signal task, compared with individuals with LTA. Such oscillatory activity was positively correlated with the CFQ score. There was no significant between-group difference of the brain activation in the Go-Nogo task. Limitations: Future studies can recruit both individuals with trait anxiety and anxiety disorders to clarify the boundaries between healthy and pathological worries in terms of cancellation ability. Conclusions: cancellation, but not restraint, is modulated by trait anxiety.
KW - Brain oscillation
KW - Cognitive Failures Questionnaire (CFQ)
KW - Inhibitory function
KW - N2
KW - P3
UR - http://www.scopus.com/inward/record.url?scp=85120752667&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2021.11.066
DO - 10.1016/j.jad.2021.11.066
M3 - Article
C2 - 34863714
AN - SCOPUS:85120752667
SN - 0165-0327
VL - 299
SP - 188
EP - 195
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -