Brain manifestation and modulation of pain from myofascial trigger points

David M. Niddam*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


The brain plays a prominent role in the generation and modulation of pain. It contains powerful endogenous pain modulatory systems that can be engaged in a beneficial way by therapeutical intervention. In contrast, pain chronification is associated with maladaptive structural and functional changes that may shift the balance of the modulatory systems. Although pain from myofascial trigger points (MTrPs) is highly prevalent, little is known about its brain manifestations and modulation. Recent neuroimaging data suggest that hyperalgesia from MTrPs is processed in similar regions as hyperalgesia from other pain conditions. However, abnormal hippocampal hypoactivity suggests that dysfunctional stress responses may play an important role in the generation and maintenance of hyperalgesia from MTrPs. Other data suggest that short-term pain relief obtained with intramuscular electrostimulation within an MTrP is partially due to descending pain inhibitory mechanisms.

Original languageEnglish
Pages (from-to)370-375
Number of pages6
JournalCurrent Pain and Headache Reports
Issue number5
StatePublished - 2009


Dive into the research topics of 'Brain manifestation and modulation of pain from myofascial trigger points'. Together they form a unique fingerprint.

Cite this