Biothiol-triggered, self-disassembled silica nanobeads for intracellular drug delivery

Xin Chun Huang, Li Bang Wu, Jen Fang Hsu, Shinsuke Shigeto, Hsin-Yun Hsu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Silica-based nanomaterials have demonstrated great potential in biomedical applications due to their chemical inertness. However, the degradability and endosomal trapping issues remain as rate-limiting barriers during their innovation. In this study, we provide a simple yet novel sol-gel approach to construct the redox-responsive silica nanobeads (ReSiNs), which could be rapidly disassembled upon redox gradient for intracellular drug delivery. The disulfide-linked scaffold of the nanobead was synthesized by employing the dithiobis-(succinimidyl propionate) to bridge (3-aminopropyl)-trimethoxysilane. Such silica matrix could be efficiently disrupted in response to intracellular glutathione, resulting in drug release and collapse of entire nanocarrier. Moreover, the ReSiNs exhibited insignificant cytotoxicity before and after the degradation. These results indicated the potential of using ReSiNs as a novel silica-based, biothiol-degradable nanoplatform for future drug delivery.

Original languageEnglish
Pages (from-to)263-270
Number of pages8
JournalActa Biomaterialia
StatePublished - 1 Sep 2015


  • Biothiols
  • Drug delivery
  • Self-disassembly
  • Silica nanoparticles
  • Sol-gel processes


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