Biological evaluation of dendrimers based on melamine

M. F. Neerman; A. P. Umali; H. T. Chen; S. D. Waghela; A. R. Parrish; E. E. Simanek

doi:10.1016/s1773-2247(05)50004-2

Biological evaluation of dendrimers based on melamine

M. F. Neerman, A. P. Umali, H. T. Chen, S. D. Waghela, A. R. Parrish, E. E. Simanek^*

^*Corresponding author for this work

Faculty of Pharmacy

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The synthetic strategies used to prepare dendrimers based on melamine are reviewed. The ability to control the number and positions of functional groups within third generation dendrimers has been established. Strategies for post-synthetic modification of peripheral groups and the biological consequences of such modifications in vitro and in vivo are described. The results of all biological inquiries of these systems to date (August 2004) are presented including studies of cytotoxicity, antigenicity, hemolytic potential, acute and subchronic toxicity and the reduction of drug toxicity.

Original language	English
Pages (from-to)	31-39
Number of pages	9
Journal	Journal of Drug Delivery Science and Technology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/s1773-2247(05)50004-2
State	Published - 2005

Keywords

Dendrimer
Drug delivery
Polymer therapeutics
Synthesis
Vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/s1773-2247(05)50004-2

Cite this

@article{67a37666ea554e2488e0f85392728f17,

title = "Biological evaluation of dendrimers based on melamine",

abstract = "The synthetic strategies used to prepare dendrimers based on melamine are reviewed. The ability to control the number and positions of functional groups within third generation dendrimers has been established. Strategies for post-synthetic modification of peripheral groups and the biological consequences of such modifications in vitro and in vivo are described. The results of all biological inquiries of these systems to date (August 2004) are presented including studies of cytotoxicity, antigenicity, hemolytic potential, acute and subchronic toxicity and the reduction of drug toxicity.",

keywords = "Dendrimer, Drug delivery, Polymer therapeutics, Synthesis, Vaccine",

author = "Neerman, {M. F.} and Umali, {A. P.} and Chen, {H. T.} and Waghela, {S. D.} and Parrish, {A. R.} and Simanek, {E. E.}",

year = "2005",

doi = "10.1016/s1773-2247(05)50004-2",

language = "English",

volume = "15",

pages = "31--39",

journal = "Journal of Drug Delivery Science and Technology",

issn = "1157-1489",

publisher = "Editions de Sante",

number = "1",

}

TY - JOUR

T1 - Biological evaluation of dendrimers based on melamine

AU - Neerman, M. F.

AU - Umali, A. P.

AU - Chen, H. T.

AU - Waghela, S. D.

AU - Parrish, A. R.

AU - Simanek, E. E.

PY - 2005

Y1 - 2005

N2 - The synthetic strategies used to prepare dendrimers based on melamine are reviewed. The ability to control the number and positions of functional groups within third generation dendrimers has been established. Strategies for post-synthetic modification of peripheral groups and the biological consequences of such modifications in vitro and in vivo are described. The results of all biological inquiries of these systems to date (August 2004) are presented including studies of cytotoxicity, antigenicity, hemolytic potential, acute and subchronic toxicity and the reduction of drug toxicity.

AB - The synthetic strategies used to prepare dendrimers based on melamine are reviewed. The ability to control the number and positions of functional groups within third generation dendrimers has been established. Strategies for post-synthetic modification of peripheral groups and the biological consequences of such modifications in vitro and in vivo are described. The results of all biological inquiries of these systems to date (August 2004) are presented including studies of cytotoxicity, antigenicity, hemolytic potential, acute and subchronic toxicity and the reduction of drug toxicity.

KW - Dendrimer

KW - Drug delivery

KW - Polymer therapeutics

KW - Synthesis

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=13444303908&partnerID=8YFLogxK

U2 - 10.1016/s1773-2247(05)50004-2

DO - 10.1016/s1773-2247(05)50004-2

M3 - Review article

AN - SCOPUS:13444303908

SN - 1157-1489

VL - 15

SP - 31

EP - 39

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

IS - 1

ER -

Biological evaluation of dendrimers based on melamine

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this