Bioinspired assembly of functional block-copolymer nanotemplates

I. Hong Lin, Chih Chia Cheng*, Wei Tsung Chuang, Jem Kun Chen, U. Ser Jeng, Fu-Hsiang Ko, Chih Wei Chu, Chih Feng Huang, Feng Chih Chang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A new concept on bioinspired assembly of functional diblock copolymers, capable of forming different microstructures through nucleobase-induced supramolecular interactions, has been explored. In this paper, a new series of uracil-functionalized poly(ε-caprolactone)-b-(4-vinylbenzyl uracil)s (PCL-b-PVBU) have been prepared which exhibit a high self-complementary ability in solution and solid states owing to the formation of uracil-uracil pairs by induced hierarchical self-assembly. The ordered morphologies of PCL-b-PVBU diblock copolymers changed from a lamellar, hexagonally packed cylinder to a sphere with respect to the content of the hydrogen bond segment. Moreover, we further show that the PCL segment could be easily extracted by enzymatic degradation, leading to a cylinder porous structure of long-range order, which gives a facile method for the fabrication of uracil-functionalized nanotemplates. In addition, bio-complementary PCL-b-PVBU/9-hexadecyladenine (AC16) hierarchical supramolecular complexes formed through strong cooperative hydrogen bonding between the uracil group of PVBU and the adenine group of A-C16. When the mixing ratios of PCL-b-PVBU/AC16 differ from the stoichiometric ratio, these complexes self-assemble into well-ordered lamellar and hexagonal structures; the changing morphology at different AC16 loadings reveals that the molecular structures of the PCL-b-PVBU/AC16 complexes are readily tailored.

Original languageEnglish
Pages (from-to)9608-9614
Number of pages7
JournalSoft Matter
Volume9
Issue number40
DOIs
StatePublished - 28 Oct 2013

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