Abstract
Chemical investigation of the nonpolar extract of soft coral Clavularia viridis resulted in isolation of five new prostanoids, designated as claviridic acids A-E (1-5, resp.), in addition to the known clavulones I-III. Their structures were determined on the basis of spectroscopic techniques, especially HR-ESI-MS, CD, and 2D-NMR experiments. The isolated marine prostanoids exhibited potent inhibitory effect on PHA-induced proliferation of peripheral blood mononuclear cells (PBMC), as well as significant cytotoxic activity against human gastric cancer cells (AGS).
Original language | English |
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Pages (from-to) | 784-792 |
Number of pages | 9 |
Journal | Chemistry and Biodiversity |
Volume | 5 |
Issue number | 5 |
DOIs | |
State | Published - 2008 |