Automatic classification of myocardial infarction using spline representation of single-lead derived vectorcardiography

Yu Hung Chuang, Chia Ling Huang, Wen-Whei Chang*, Jen-Tzung Chien

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Myocardial infarction (MI) is one of the most prevalent cardiovascular diseases worldwide and most patients suffer from MI without awareness. Therefore, early diagnosis and timely treatment are crucial to guarantee the life safety of MI patients. Most wearable monitoring devices only provide single-lead electrocardiography (ECG), which represents a major limitation for their applicability in diagnosis of MI. Incorporating the derived vectorcardiography (VCG) techniques can help monitor the three-dimensional electrical activities of human hearts. This study presents a patient-specific reconstruction method based on long short-term memory (LSTM) network to exploit both intra-and inter-lead correlations of ECG signals. MI-induced changes in the morphological and temporal wave features are extracted from the derived VCG using spline approximation. After the feature extraction, a classifier based on multilayer perceptron network is used for MI classification. Experiments on PTB diagnostic database demonstrate that the proposed system achieved satisfactory performance to differentiating MI patients from healthy subjects and to localizing the infarcted area.

Original languageAmerican English
Article number7246
Pages (from-to)1-18
Number of pages18
JournalSensors (Switzerland)
Issue number24
StatePublished - 2 Dec 2020


  • Electrocardiography
  • Long short-term memory
  • Multilayer perceptron
  • Myocardial infarction
  • Spline
  • Vectorcardiography


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