Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade

Angelika Gutenberg; Melissa Landek-Salgado; Shey-Cherng Tzou; Isabella Lupi; Abby Geis; Hiroaki Kimura; Patrizio Caturegli

doi:10.1586/eem.09.37

Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade

Angelika Gutenberg, Melissa Landek-Salgado, Shey-Cherng Tzou, Isabella Lupi, Abby Geis, Hiroaki Kimura, Patrizio Caturegli^*

^*Corresponding author for this work

Institute of Molecular Medicine and Bioengineering

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.

Original language	English
Pages (from-to)	681-698
Number of pages	18
Journal	Expert Review of Endocrinology and Metabolism
Volume	4
Issue number	6
DOIs	https://doi.org/10.1586/eem.09.37
State	Published - Nov 2009

Keywords

Autoimmunity
CTLA-4 blockade
Hypophysitis
MRI
Monoclonal antibodies
Nonfunctioning sellar masses

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1586/eem.09.37

Cite this

@article{3de1fbf9936c41518ced49fb1c6d593b,

title = "Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade",

abstract = "Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.",

keywords = "Autoimmunity, CTLA-4 blockade, Hypophysitis, MRI, Monoclonal antibodies, Nonfunctioning sellar masses",

author = "Angelika Gutenberg and Melissa Landek-Salgado and Shey-Cherng Tzou and Isabella Lupi and Abby Geis and Hiroaki Kimura and Patrizio Caturegli",

year = "2009",

month = nov,

doi = "10.1586/eem.09.37",

language = "English",

volume = "4",

pages = "681--698",

journal = "Expert Review of Endocrinology and Metabolism",

issn = "1744-6651",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - Autoimmune hypophysitis

T2 - Expanding the differential diagnosis to CTLA-4 blockade

AU - Gutenberg, Angelika

AU - Landek-Salgado, Melissa

AU - Tzou, Shey-Cherng

AU - Lupi, Isabella

AU - Geis, Abby

AU - Kimura, Hiroaki

AU - Caturegli, Patrizio

PY - 2009/11

Y1 - 2009/11

N2 - Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.

AB - Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.

KW - Autoimmunity

KW - CTLA-4 blockade

KW - Hypophysitis

KW - MRI

KW - Monoclonal antibodies

KW - Nonfunctioning sellar masses

UR - http://www.scopus.com/inward/record.url?scp=70449941268&partnerID=8YFLogxK

U2 - 10.1586/eem.09.37

DO - 10.1586/eem.09.37

M3 - Review article

AN - SCOPUS:70449941268

SN - 1744-6651

VL - 4

SP - 681

EP - 698

JO - Expert Review of Endocrinology and Metabolism

JF - Expert Review of Endocrinology and Metabolism

IS - 6

ER -

Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this