Autoimmune disease comorbidities in patients with atopic dermatitis: A nationwide case-control study in Taiwan

Lung Chi Wu, Chian Yaw Hwang, Pei I. Chung, Tuan Chun Hua, Yen Da Chen, Szu Yin Chu, Din Dar Lee, Yun Ting Chang, Wen Jen Wang, Han Nan Liu, Chih Chiang Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Background and Objectives: Atopic dermatitis (AD) is a chronic relapsing dermatitis of unknown etiology. It is thought that abnormal regulation of Th1 and Th2 is not only the major cause of AD, but also the vital pathogenesis of many autoimmune diseases. To date, no large-scale studies have been performed on the relationship between AD and autoimmune disease. By conducting a nationwide population-based study with case-controls in Taiwan, we sought to clarify the association of AD with other autoimmune diseases to obtain a better understanding of its pathogenesis. Methods: Data were obtained from the National Health Insurance Research Database (NHIRD) of Taiwan from 1997 to 2010. In total, 41950 patients with AD and 167800 age- and gender-matched controls were enrolled. Results: Patients with AD tended to have a high risk of associated lupus erythematosus (LE) (OR: 1.94, 95% CI: 1.48-2.54). The risk of LE was higher in female AD patients (OR: 2.05, 95% CI: 1.53-2.76) than in male AD patients (OR: 1.48, 95% CI: 0.76-2.85). Juvenile patients younger than 18 yrs with AD had higher risk of LE (OR: 3.02, 95% CI: 1.30-7.03) than adult patients with AD (OR: 1.68, 95% CI: 1.26-2.24). Conclusions: Our study confirmed the association between AD and LE. Early survey for LE in juvenile patients with AD is recommended.

Original languageEnglish
Pages (from-to)586-592
Number of pages7
JournalPediatric Allergy and Immunology
Issue number6
StatePublished - 1 Oct 2014


  • Atopic dermatitis
  • Autoimmune disease
  • Nationwide
  • Systemic lupus erythematosus


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