Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

Ya Shih Tseng; Ching Cherng Tzeng; Chi Ying F. Huang; Ping Hong Chen; Allen Wen Hsiang Chiu; Pei Yin Hsu; Guan Cheng Huang; Yu Chun Wang; Hsiao Sheng Liu

doi:10.1016/j.canlet.2005.10.014

Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

Ya Shih Tseng, Ching Cherng Tzeng, Chi Ying F. Huang, Ping Hong Chen, Allen Wen Hsiang Chiu, Pei Yin Hsu, Guan Cheng Huang, Yu Chun Wang, Hsiao Sheng Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.

Original language	English
Pages (from-to)	93-101
Number of pages	9
Journal	Cancer Letters
Volume	241
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2005.10.014
State	Published - 8 Sep 2006

Keywords

Arsenic
Aurora-A
Blackfoot-endemic-area
Ha-ras mutation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2005.10.014

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@article{3af1c723ebfd485291cfa4504b346026,

title = "Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer",

abstract = "Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.",

keywords = "Arsenic, Aurora-A, Blackfoot-endemic-area, Ha-ras mutation",

author = "Tseng, {Ya Shih} and Tzeng, {Ching Cherng} and Huang, {Chi Ying F.} and Chen, {Ping Hong} and Chiu, {Allen Wen Hsiang} and Hsu, {Pei Yin} and Huang, {Guan Cheng} and Wang, {Yu Chun} and Liu, {Hsiao Sheng}",

note = "Funding Information: This work was supported by grant CMFHR9316 from the Chi-Mei Medical Center and grant NSC93-2321-B006-009 from the National Science Council, Taiwan, ROC. ",

year = "2006",

month = sep,

day = "8",

doi = "10.1016/j.canlet.2005.10.014",

language = "English",

volume = "241",

pages = "93--101",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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}

TY - JOUR

T1 - Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

AU - Tseng, Ya Shih

AU - Tzeng, Ching Cherng

AU - Huang, Chi Ying F.

AU - Chen, Ping Hong

AU - Chiu, Allen Wen Hsiang

AU - Hsu, Pei Yin

AU - Huang, Guan Cheng

AU - Wang, Yu Chun

AU - Liu, Hsiao Sheng

N1 - Funding Information: This work was supported by grant CMFHR9316 from the Chi-Mei Medical Center and grant NSC93-2321-B006-009 from the National Science Council, Taiwan, ROC.

PY - 2006/9/8

Y1 - 2006/9/8

N2 - Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.

AB - Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.

KW - Arsenic

KW - Aurora-A

KW - Blackfoot-endemic-area

KW - Ha-ras mutation

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U2 - 10.1016/j.canlet.2005.10.014

DO - 10.1016/j.canlet.2005.10.014

M3 - Article

C2 - 16338065

AN - SCOPUS:39049177016

SN - 0304-3835

VL - 241

SP - 93

EP - 101

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

Abstract

Keywords

UN SDGs

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