Au-Ag core-shell nanoparticles with controllable shell thicknesses for the detection of adenosine by surface enhanced Raman scattering

Fu-Hsiang Ko; Ming Rou Tai; Fu Ken Liu; Yu Cheng Chang

doi:10.1016/j.snb.2015.01.047

Au-Ag core-shell nanoparticles with controllable shell thicknesses for the detection of adenosine by surface enhanced Raman scattering

Fu-Hsiang Ko, Ming Rou Tai, Fu Ken Liu, Yu Cheng Chang^*

^*Corresponding author for this work

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

In this study, we report a feasible aqueous chemical method to synthesize Au core-Ag shell nanoparticles (NPs) by seeding growth approach. The concentration of Au NPs plays an important role in growing the different thicknesses of Ag shells. The design of signaling aptamer utilizes the target-induced switching between an aptamer/DNA duplex and an aptamer/target complex. The surface enhanced Raman scattering (SERS) signal was enhanced upon the hybridization of the Raman reporter-labeled DNA released from the target-induced displacement with the captured DNA immobilized on the silicon substrate with Au-Ag core-shell NPs. This substrate with 12.4 nm Ag shell shows high reproducibility, strong enhancement, and a low detection limit (1 nM). The enhancement in DNA-based adenosine detection properties shall be advantageous in applications for other aptamer sensing systems.

Original language	English
Pages (from-to)	283-289
Number of pages	7
Journal	Sensors and Actuators, B: Chemical
Volume	211
DOIs	https://doi.org/10.1016/j.snb.2015.01.047
State	Published - 1 Jan 2015

Keywords

Adenosine
Aptamer
Nanoparticles
Raman scattering
Seeding growth
Surface enhanced

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title = "Au-Ag core-shell nanoparticles with controllable shell thicknesses for the detection of adenosine by surface enhanced Raman scattering",

abstract = "In this study, we report a feasible aqueous chemical method to synthesize Au core-Ag shell nanoparticles (NPs) by seeding growth approach. The concentration of Au NPs plays an important role in growing the different thicknesses of Ag shells. The design of signaling aptamer utilizes the target-induced switching between an aptamer/DNA duplex and an aptamer/target complex. The surface enhanced Raman scattering (SERS) signal was enhanced upon the hybridization of the Raman reporter-labeled DNA released from the target-induced displacement with the captured DNA immobilized on the silicon substrate with Au-Ag core-shell NPs. This substrate with 12.4 nm Ag shell shows high reproducibility, strong enhancement, and a low detection limit (1 nM). The enhancement in DNA-based adenosine detection properties shall be advantageous in applications for other aptamer sensing systems.",

keywords = "Adenosine, Aptamer, Nanoparticles, Raman scattering, Seeding growth, Surface enhanced",

author = "Fu-Hsiang Ko and Tai, {Ming Rou} and Liu, {Fu Ken} and Chang, {Yu Cheng}",

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T1 - Au-Ag core-shell nanoparticles with controllable shell thicknesses for the detection of adenosine by surface enhanced Raman scattering

AU - Ko, Fu-Hsiang

AU - Tai, Ming Rou

AU - Liu, Fu Ken

AU - Chang, Yu Cheng

PY - 2015/1/1

Y1 - 2015/1/1

N2 - In this study, we report a feasible aqueous chemical method to synthesize Au core-Ag shell nanoparticles (NPs) by seeding growth approach. The concentration of Au NPs plays an important role in growing the different thicknesses of Ag shells. The design of signaling aptamer utilizes the target-induced switching between an aptamer/DNA duplex and an aptamer/target complex. The surface enhanced Raman scattering (SERS) signal was enhanced upon the hybridization of the Raman reporter-labeled DNA released from the target-induced displacement with the captured DNA immobilized on the silicon substrate with Au-Ag core-shell NPs. This substrate with 12.4 nm Ag shell shows high reproducibility, strong enhancement, and a low detection limit (1 nM). The enhancement in DNA-based adenosine detection properties shall be advantageous in applications for other aptamer sensing systems.

AB - In this study, we report a feasible aqueous chemical method to synthesize Au core-Ag shell nanoparticles (NPs) by seeding growth approach. The concentration of Au NPs plays an important role in growing the different thicknesses of Ag shells. The design of signaling aptamer utilizes the target-induced switching between an aptamer/DNA duplex and an aptamer/target complex. The surface enhanced Raman scattering (SERS) signal was enhanced upon the hybridization of the Raman reporter-labeled DNA released from the target-induced displacement with the captured DNA immobilized on the silicon substrate with Au-Ag core-shell NPs. This substrate with 12.4 nm Ag shell shows high reproducibility, strong enhancement, and a low detection limit (1 nM). The enhancement in DNA-based adenosine detection properties shall be advantageous in applications for other aptamer sensing systems.

KW - Adenosine

KW - Aptamer

KW - Nanoparticles

KW - Raman scattering

KW - Seeding growth

KW - Surface enhanced

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JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -

Au-Ag core-shell nanoparticles with controllable shell thicknesses for the detection of adenosine by surface enhanced Raman scattering

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Keywords

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