Atopic diathesis in patients with kawasaki disease

Chian Yaw Hwang, Yu Ya Hwang, Yi Ju Chen, Chih Chiang Chen, Ming Wei Lin, Tzeng Ji Chen, Ding Dar Lee, Yun Ting Chang*, Wen Jeng Wang, Han Nan Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Objective: To determine the association between Kawasaki disease (KD) and atopic diathesis (atopic dermatitis [AD], allergic rhinitis, and asthma) in children younger than 5 years of age. Study design: In this nationwide study, we aimed to analyze the association and temporal relationship between KD and atopic diathesis. Data were obtained from the National Health Insurance Research Database of Taiwan from 1997 to 2010. In total, 200 patients with KD younger than 5 years of age and 800 age- and sex-matched control subjects were enrolled. Results: In the whole study population, an increased risk of any concomitant atopic diseases was observed in patients with KD (OR 1.61, 95% CI 1.15-2.26). The risk of AD was increased in male patients between 1 and 5 years of age (OR 3.02, 95% CI 1.22-7.50). More than 60% of the patients developed atopic diseases after the diagnosis of KD. Conclusion: There appears to be an association between KD and risk of AD. Most of the atopic diseases occurred after the episode of KD.

Original languageEnglish
Pages (from-to)811-815
Number of pages5
JournalJournal of Pediatrics
Volume163
Issue number3
DOIs
StatePublished - Sep 2013

Keywords

  • AD
  • Allergic rhinitis
  • AR
  • Atopic dermatitis
  • CAA
  • Coronary artery aneurysm
  • ICD-9
  • International Classification of Diseases, Ninth Revision
  • Kawasaki disease
  • KD
  • LHID2000
  • Longitudinal Health Insurance Database 2000

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