Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression

Pei Shi Hung; Kuo Wei Chang; Shou Yen Kao; Ting Hui Chu; Chung Ji Liu; Shu Chun Lin

doi:10.1016/j.oraloncology.2011.11.019

Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression

Pei Shi Hung, Kuo Wei Chang, Shou Yen Kao, Ting Hui Chu, Chung Ji Liu, Shu Chun Lin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

MicroRNAs are short non-coding RNAs that regulate gene expression by RNA interference. Oral squamous cell carcinoma (OSCC) is a prevalent malignancy worldwide. miR-146a has been reported to regulate Toll-like receptors and cytokine signaling, which are both crucial for inflammation and oncogenesis. This study identifies that areca nut extract, TNFα and TGFβ up-regulates miR-146a in OSCC cells. The increased expression of miR-146a enhanced the oncogenicity of OSCC cells. In addition, a G to C polymorphism (rs2910164), which is located in the pre-miR-146a and has been associated with functional alterations in miR-146a, was significantly more prevalent among OSCC patients having more advanced nodal involvement. Our analysis also suggested a higher miR-146a expression in OSCC tissues of patients carrying C polymorphism. The present study concluded a higher prevalence of the pre-mir-146a C-variant was associated with OSCC progression in patients with this disease.

Original language	English
Pages (from-to)	404-408
Number of pages	5
Journal	Oral Oncology
Volume	48
Issue number	5
DOIs	https://doi.org/10.1016/j.oraloncology.2011.11.019
State	Published - May 2012

Keywords

Carcinoma
MicroRNA
miR-146a
Mouth
Polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2011.11.019

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title = "Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression",

abstract = "MicroRNAs are short non-coding RNAs that regulate gene expression by RNA interference. Oral squamous cell carcinoma (OSCC) is a prevalent malignancy worldwide. miR-146a has been reported to regulate Toll-like receptors and cytokine signaling, which are both crucial for inflammation and oncogenesis. This study identifies that areca nut extract, TNFα and TGFβ up-regulates miR-146a in OSCC cells. The increased expression of miR-146a enhanced the oncogenicity of OSCC cells. In addition, a G to C polymorphism (rs2910164), which is located in the pre-miR-146a and has been associated with functional alterations in miR-146a, was significantly more prevalent among OSCC patients having more advanced nodal involvement. Our analysis also suggested a higher miR-146a expression in OSCC tissues of patients carrying C polymorphism. The present study concluded a higher prevalence of the pre-mir-146a C-variant was associated with OSCC progression in patients with this disease.",

keywords = "Carcinoma, MicroRNA, miR-146a, Mouth, Polymorphism",

author = "Hung, {Pei Shi} and Chang, {Kuo Wei} and Kao, {Shou Yen} and Chu, {Ting Hui} and Liu, {Chung Ji} and Lin, {Shu Chun}",

note = "Funding Information: We acknowledge the helps from National Yang-Ming University VYM Genome Research Center for SNP analysis. This study was supported by grant V99C1-083 from Taipei Veterans General Hospital ; grant NSC99-2628-B-010-013-MY3 from National Science Council and Aim for the Top University Plan from Department of Education. Dr. Hung, P.S. was supported by a fellowship grant 099-2811-B-010-028 from NSC , Taiwan.",

year = "2012",

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doi = "10.1016/j.oraloncology.2011.11.019",

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AU - Hung, Pei Shi

AU - Chang, Kuo Wei

AU - Kao, Shou Yen

AU - Chu, Ting Hui

AU - Liu, Chung Ji

AU - Lin, Shu Chun

N1 - Funding Information: We acknowledge the helps from National Yang-Ming University VYM Genome Research Center for SNP analysis. This study was supported by grant V99C1-083 from Taipei Veterans General Hospital ; grant NSC99-2628-B-010-013-MY3 from National Science Council and Aim for the Top University Plan from Department of Education. Dr. Hung, P.S. was supported by a fellowship grant 099-2811-B-010-028 from NSC , Taiwan.

PY - 2012/5

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N2 - MicroRNAs are short non-coding RNAs that regulate gene expression by RNA interference. Oral squamous cell carcinoma (OSCC) is a prevalent malignancy worldwide. miR-146a has been reported to regulate Toll-like receptors and cytokine signaling, which are both crucial for inflammation and oncogenesis. This study identifies that areca nut extract, TNFα and TGFβ up-regulates miR-146a in OSCC cells. The increased expression of miR-146a enhanced the oncogenicity of OSCC cells. In addition, a G to C polymorphism (rs2910164), which is located in the pre-miR-146a and has been associated with functional alterations in miR-146a, was significantly more prevalent among OSCC patients having more advanced nodal involvement. Our analysis also suggested a higher miR-146a expression in OSCC tissues of patients carrying C polymorphism. The present study concluded a higher prevalence of the pre-mir-146a C-variant was associated with OSCC progression in patients with this disease.

AB - MicroRNAs are short non-coding RNAs that regulate gene expression by RNA interference. Oral squamous cell carcinoma (OSCC) is a prevalent malignancy worldwide. miR-146a has been reported to regulate Toll-like receptors and cytokine signaling, which are both crucial for inflammation and oncogenesis. This study identifies that areca nut extract, TNFα and TGFβ up-regulates miR-146a in OSCC cells. The increased expression of miR-146a enhanced the oncogenicity of OSCC cells. In addition, a G to C polymorphism (rs2910164), which is located in the pre-miR-146a and has been associated with functional alterations in miR-146a, was significantly more prevalent among OSCC patients having more advanced nodal involvement. Our analysis also suggested a higher miR-146a expression in OSCC tissues of patients carrying C polymorphism. The present study concluded a higher prevalence of the pre-mir-146a C-variant was associated with OSCC progression in patients with this disease.

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KW - MicroRNA

KW - miR-146a

KW - Mouth

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Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression

Abstract

Keywords

UN SDGs

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