Association between gout and abdominal aortic aneurysm

Jen Chun Wang, Shih Hung Tsai*, Wu Chien Chien, Chi Hsiang Chung, Shing Jong Lin, Yung Tai Chen, Po Hsun Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Previous studies have shown an association between hyperuricemia and microvascular diseases, but the association between uric acid and abdominal aortic aneurysm (AAA) remains unclear. The aim of this study was to determine the relationship between gout and AAA. Methods: A population-based cohort study was conducted to validate the association between gout and AAA formation. The outcome in this study was the cumulative incidence of AAA in patients with or without gout during the 14-year follow-up period. Results: Our analysis included 121,236 patients with gout and 121,236 propensity score-matched controls from the National Health Insurance Research Database in Taiwan. Compared to the controls, patients who had gout exhibited a significantly increased incidence of AAA development [adjusted hazard ratio (HR) = 2.465, p < 0.001]. We also found that patients who were treated with anti-gout medications had a significantly lower risk of being diagnosed with an AAA than patients who were not treated with anti-gout medications (adjusted HR = 0.489, p < 0.001). Conclusions: We have provided clinical evidence that gout is associated with the development of AAA.

Original languageEnglish
Pages (from-to)274-278
Number of pages5
JournalJournal of Cardiology
Volume82
Issue number4
DOIs
StatePublished - Oct 2023

Keywords

  • Abdominal aortic aneurysm
  • Hyperuricemia
  • Uric acid

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