Associated clinical characteristics of patients with candidemia among different Candida species

Liang Yu Chen, Shu Chen Kuo, Hau Shin Wu, Su Pen Yang, Yu Jiun Chan, Liang Kung Chen, Fu Der Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background: The rising incidence of non. -albicans Candida (NAC) infection has been associated with a potentially adverse outcome for patients with candidemia. However, categorizing various species causing candidemia into a single NAC group might lead to inappropriate conclusions due to heterogeneity in species. Thus we examined the associated factors among patients with candidemia caused by different species. Methods: This retrospective study was conducted at a tertiary medical center in Taiwan from 2006 to 2009. Mortality rate, demographic and clinical characteristics, albumin levels, and severity scores of acute illness of patients at the onset of candidemia were analyzed. Results: A total of 447 episodes among 418 patients were included for analysis. The overall 30-day crude mortality was 48.2%, with no significant difference between C. albicans and NAC candidemia, but apparently C. parapsilosis candidemia was associated with a lower mortality rate. Time to positivity for yeast was significantly different between species. Compared with infection involving C. albicans, more frequent use of total parenteral nutrition, lower Sequential Organ Failure Assessment score and higher albumin levels were observed for C. parapsilosis candidemia. Conclusion: Identifying associated factors for each species may be a more effective approach than single NAC grouping. Time to positivity may be a hint for treatment guidance in candidemia. More frequent use of total parenteral nutrition and less virulent nature were noted for C. parapsilosis candidemia.

Original languageEnglish
Pages (from-to)463-468
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Issue number6
StatePublished - Dec 2013


  • Candidemia
  • Non-albicans Candida species
  • Time to positivity
  • Total parenteral nutrition


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