Assessment of preferred methods to measure insulin resistance in Asian patients with hypertension

Huynh Van Minh*, Hoang Anh Tien, Cao Thuc Sinh, Doan Chi Thang, Chen Huan Chen, Jam Chin Tay, Saulat Siddique, Tzung Dau Wang, Guru Prasad Sogunuru, Yook Chin Chia, Kazuomi Kario

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations


Insulin resistance (IR), a metabolic risk factor, is linked to the pathogenetic mechanism of primary hypertension. Detecting IR in the patients with hypertension will help to predict and stratify the added cardiovascular risk, institute appropriate IR management, and manage hypertension optimally. There are many methods for assessing IR, each with distinct advantages and disadvantages. The euglycemic insulin clamp and intravenous glucose tolerance test, gold standards for measuring IR, are used in research but not in clinical practice. Homeostatic model assessment (HOMA-IR), a method for assessing β-cell function and IR, is frequently applied presently, particularly in Asia. Besides, the triglyceride–glucose index (TyG) first published by South American authors showed a good correlation with the insulin clamp technique and HOMA-IR index. This simple, convenient, and low-cost TyG index is of research interest in many countries in Asia and can be used to screen for IR in the Asian hypertensive community.

Original languageEnglish
Pages (from-to)529-537
Number of pages9
JournalJournal of Clinical Hypertension
Issue number3
StatePublished - Mar 2021


  • Asia patients
  • hypertension
  • insulin resistance


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