Assessment of left ventricular dysfunction in children undergoing chemotherapy

Chien Chang Juan, Betau Hwang, Giun Yi Hung, Pi Chang Lee*, C. C.Laura Meng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In Taiwan, children with malignancies are treated under the protocols of the Taiwan Pediatric Oncology Group (TPOG). The purpose of this study was to determine the change in left ventricular (LV) function in pediatric patients undergoing chemotherapy. Methods: A total of 19 pediatric patients (mean age, 12.5±4.6 years; 11 males, 8 females) were enrolled. We divided the patients into 2 groups: (1) osteogenic sarcoma (OGS) group (n=12; Group I); and (2) non-osteogenic sarcoma (non-OGS) group (n=7; Group II). The accumulated dosages of anthracycline in Group I and II patients were 144.3±56.4 mg/M2 and 131.7±105.5mg/M2 (p=0.735), respectively. The children received echocardiography to investigate the parameters of LV systolic function, LV diastolic function, and myocardial performance index (MPI) after the entire chemotherapy course. Results: Higher E/A ratio (1.71±0.37), shorter isovolumic relaxation time (IRT, 42±19.14 ms), and shorter deceleration time (DT, 140.3±40.6 ms) were demonstrated in these patients. There was no statistically significant difference in the E/A ratio and DT between the 2 groups. Group I children were older (14.4±3.7 vs. 9.3±4.5 years; p=0.015) and had lower MPI (0.20±0.02 vs. 0.28±0.07; p=0.031) than Group II children. Conclusion: The children treated with chemotherapy using the TPOG protocol had a shorter IRT, higher E/A ratio and shorter DT. No significant evidence of anthracycline-related cardiotoxicity was found in any of the children in this study undergoing chemotherapy with the TPOG protocol.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalJournal of the Chinese Medical Association
Volume70
Issue number6
DOIs
StatePublished - Jun 2007

Keywords

  • Anthracycline
  • Chemotherapy
  • Children
  • Left ventricular dysfunction

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