TY - JOUR
T1 - Assessment of left ventricular dysfunction in children undergoing chemotherapy
AU - Juan, Chien Chang
AU - Hwang, Betau
AU - Hung, Giun Yi
AU - Lee, Pi Chang
AU - Meng, C. C.Laura
PY - 2007/6
Y1 - 2007/6
N2 - Background: In Taiwan, children with malignancies are treated under the protocols of the Taiwan Pediatric Oncology Group (TPOG). The purpose of this study was to determine the change in left ventricular (LV) function in pediatric patients undergoing chemotherapy. Methods: A total of 19 pediatric patients (mean age, 12.5±4.6 years; 11 males, 8 females) were enrolled. We divided the patients into 2 groups: (1) osteogenic sarcoma (OGS) group (n=12; Group I); and (2) non-osteogenic sarcoma (non-OGS) group (n=7; Group II). The accumulated dosages of anthracycline in Group I and II patients were 144.3±56.4 mg/M2 and 131.7±105.5mg/M2 (p=0.735), respectively. The children received echocardiography to investigate the parameters of LV systolic function, LV diastolic function, and myocardial performance index (MPI) after the entire chemotherapy course. Results: Higher E/A ratio (1.71±0.37), shorter isovolumic relaxation time (IRT, 42±19.14 ms), and shorter deceleration time (DT, 140.3±40.6 ms) were demonstrated in these patients. There was no statistically significant difference in the E/A ratio and DT between the 2 groups. Group I children were older (14.4±3.7 vs. 9.3±4.5 years; p=0.015) and had lower MPI (0.20±0.02 vs. 0.28±0.07; p=0.031) than Group II children. Conclusion: The children treated with chemotherapy using the TPOG protocol had a shorter IRT, higher E/A ratio and shorter DT. No significant evidence of anthracycline-related cardiotoxicity was found in any of the children in this study undergoing chemotherapy with the TPOG protocol.
AB - Background: In Taiwan, children with malignancies are treated under the protocols of the Taiwan Pediatric Oncology Group (TPOG). The purpose of this study was to determine the change in left ventricular (LV) function in pediatric patients undergoing chemotherapy. Methods: A total of 19 pediatric patients (mean age, 12.5±4.6 years; 11 males, 8 females) were enrolled. We divided the patients into 2 groups: (1) osteogenic sarcoma (OGS) group (n=12; Group I); and (2) non-osteogenic sarcoma (non-OGS) group (n=7; Group II). The accumulated dosages of anthracycline in Group I and II patients were 144.3±56.4 mg/M2 and 131.7±105.5mg/M2 (p=0.735), respectively. The children received echocardiography to investigate the parameters of LV systolic function, LV diastolic function, and myocardial performance index (MPI) after the entire chemotherapy course. Results: Higher E/A ratio (1.71±0.37), shorter isovolumic relaxation time (IRT, 42±19.14 ms), and shorter deceleration time (DT, 140.3±40.6 ms) were demonstrated in these patients. There was no statistically significant difference in the E/A ratio and DT between the 2 groups. Group I children were older (14.4±3.7 vs. 9.3±4.5 years; p=0.015) and had lower MPI (0.20±0.02 vs. 0.28±0.07; p=0.031) than Group II children. Conclusion: The children treated with chemotherapy using the TPOG protocol had a shorter IRT, higher E/A ratio and shorter DT. No significant evidence of anthracycline-related cardiotoxicity was found in any of the children in this study undergoing chemotherapy with the TPOG protocol.
KW - Anthracycline
KW - Chemotherapy
KW - Children
KW - Left ventricular dysfunction
UR - http://www.scopus.com/inward/record.url?scp=34447544077&partnerID=8YFLogxK
U2 - 10.1016/S1726-4901(09)70366-1
DO - 10.1016/S1726-4901(09)70366-1
M3 - Article
C2 - 17591583
AN - SCOPUS:34447544077
SN - 1726-4901
VL - 70
SP - 241
EP - 244
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
IS - 6
ER -