Assessing the cognitive status of Drosophila by the value-based feeding decision

Chih Chieh Yu; Ferng Chang Chang; Yong Huei Hong; Jian Chiuan Li; Po Lin Chen; Chun Hong Chen; Tzai Wen Chiu; Tsai Te Lu; Yun Ming Wang; Chih Fei Kao

doi:10.1038/s41514-021-00075-6

Assessing the cognitive status of Drosophila by the value-based feeding decision

Chih Chieh Yu, Ferng Chang Chang, Yong Huei Hong, Jian Chiuan Li, Po Lin Chen, Chun Hong Chen, Tzai Wen Chiu, Tsai Te Lu, Yun Ming Wang, Chih Fei Kao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Decision-making is considered an important aspect of cognitive function. Impaired decision-making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploited the value-based feeding decision (VBFD) assay, which is a simple sensory–motor task, to determine the cognitive status of Drosophila. Our results indicated the deterioration of VBFD is notably correlated with aging and neurodegenerative disorders. Restriction of the mushroom body (MB) neuronal activity partly blunted the proper VBFD. Furthermore, using the Drosophila polyQ disease model, we demonstrated the impaired VBFD is ameliorated by the dinitrosyl iron complex (DNIC-1), a novel and steady nitric oxide (NO)-releasing compound. Therefore we propose that the VBFD assay provides a robust assessment of Drosophila cognition and can be used to characterize additional neuroprotective interventions.

Original language	English
Article number	24
Journal	npj Aging and Mechanisms of Disease
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41514-021-00075-6
State	Published - Dec 2021

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title = "Assessing the cognitive status of Drosophila by the value-based feeding decision",

abstract = "Decision-making is considered an important aspect of cognitive function. Impaired decision-making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploited the value-based feeding decision (VBFD) assay, which is a simple sensory–motor task, to determine the cognitive status of Drosophila. Our results indicated the deterioration of VBFD is notably correlated with aging and neurodegenerative disorders. Restriction of the mushroom body (MB) neuronal activity partly blunted the proper VBFD. Furthermore, using the Drosophila polyQ disease model, we demonstrated the impaired VBFD is ameliorated by the dinitrosyl iron complex (DNIC-1), a novel and steady nitric oxide (NO)-releasing compound. Therefore we propose that the VBFD assay provides a robust assessment of Drosophila cognition and can be used to characterize additional neuroprotective interventions.",

author = "Yu, {Chih Chieh} and Chang, {Ferng Chang} and Hong, {Yong Huei} and Li, {Jian Chiuan} and Chen, {Po Lin} and Chen, {Chun Hong} and Chiu, {Tzai Wen} and Lu, {Tsai Te} and Wang, {Yun Ming} and Kao, {Chih Fei}",

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AU - Yu, Chih Chieh

AU - Chang, Ferng Chang

AU - Hong, Yong Huei

AU - Li, Jian Chiuan

AU - Chen, Po Lin

AU - Chen, Chun Hong

AU - Chiu, Tzai Wen

AU - Lu, Tsai Te

AU - Wang, Yun Ming

AU - Kao, Chih Fei

PY - 2021/12

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AB - Decision-making is considered an important aspect of cognitive function. Impaired decision-making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploited the value-based feeding decision (VBFD) assay, which is a simple sensory–motor task, to determine the cognitive status of Drosophila. Our results indicated the deterioration of VBFD is notably correlated with aging and neurodegenerative disorders. Restriction of the mushroom body (MB) neuronal activity partly blunted the proper VBFD. Furthermore, using the Drosophila polyQ disease model, we demonstrated the impaired VBFD is ameliorated by the dinitrosyl iron complex (DNIC-1), a novel and steady nitric oxide (NO)-releasing compound. Therefore we propose that the VBFD assay provides a robust assessment of Drosophila cognition and can be used to characterize additional neuroprotective interventions.

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Assessing the cognitive status of Drosophila by the value-based feeding decision

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