Assembly of viral membrane proteins

J. Krüger, W. B. Fischer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The generation of computational models is an alternative route to obtain reliable structures for the oligomeric state of membrane proteins. A strategy has been developed to search the conformational space of all possible assemblies in a reasonable time, taking symmetry considerations into account. The methodology tested on M2 from influenza A, shows an excellent agreement with established structures. For Vpu from HIV-1 a series of conformational distinct structures are proposed. For the first time a structural model for a fully assembled transmembrane part of 3a from SARS-CoV is proposed.

Original languageEnglish
Pages (from-to)2503-2513
Number of pages11
JournalJournal of Chemical Theory and Computation
Volume5
Issue number9
DOIs
StatePublished - Sep 2009

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