Abstract
A mild and efficient transition metal-free approach has been developed for the synthesis of highly substituted chiral morpholines from alkenols by amino acid-derived iodine(III) reagents via a 6-exo-trig cyclization. The key features of this work include the formation of three chiral centers with a high diastereomeric ratio, broad functional group compatibility, and atom/time economic methodology.
Original language | English |
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Pages (from-to) | 2788-2794 |
Number of pages | 7 |
Journal | Advanced Synthesis and Catalysis |
Volume | 357 |
Issue number | 13 |
DOIs | |
State | Published - 1 Sep 2015 |
Keywords
- 6-exo-trig cyclization
- alkenes
- halo-etherification
- morpholines
- λ-iodanes