Applications of surface enhanced spectroscopic techniques to biosystems

Gerald Steiner*, Christian Kuhne, Beate Leupolt, Wolfang B. Fischer, Reiner Salzer

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


The potential of surface enhanced spectroscopy consists in the detection of very small but specific structures of biomaterials, Surface enhanced infrared absorption (SEIRA) yields fingerprint information on the biomaterials. Electronic interactions between individual groups in the molecule are detected by means of surface enhanced fluorescence (SEF). During the investigation of biomembranes with SEIRA a tenfold intensity enhancement could be obtained. Enhancement factors greater than 100 can be achieved with SEF. Enhancement is considerably influenced by the properties of the metal cluster structure. Biomembranes formed from vesicles containing the nicotinic acetylcholine receptor were spectroscopically characterized. The adsorption of the vesicles on Ge- and Ag surfaces was investigated. The metal cluster structure was optimized in order to obtain high intensity enhancement factors.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 1998
EventAdvances in Optical Biophysics - San Jose, CA, United States
Duration: 25 Jan 199826 Jan 1998


  • Biomembrane
  • Cluster
  • Fluorescence
  • FTIR spectroscopy
  • Surface enhanced spectroscopy


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