Application of Metal-Enhanced Fluorescence technology in evanescent wave fluorescent biosensor

Yu Zheng Su*, Min Wei Hung, Wen Hong Wu, Kuo Cheng Huang, Huihua Kenny Chiang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Evanescent wave fluorescent sensors have developed for 30 years. Nonetheless, the technology continues to evolve with new breakthroughs in optics, biochemistry, and chemical engineering. Recently, there have been explosive developments in the Metal-Enhanced Fluorescence (MEF) technology to favorably modify the spectral properties and to alleviate photo-physical constraints. We report the development of core-shell nanoparticles with the silver core and SiO2 shell for potential applications in fiber optic biosensor. The fluorescence intensity of the fluorescence probe (Fluorescein isothiocyanate, FITC) doped core-shell nanoparticles was approximately 50-fold higher than that without core-shell nanoparticles doping. In addition, four different kinds of organic solvents are used in this study and found to have influence on the fluorescence intensity from 1.3 to over 100 times. We conclude that core-shell nanoparticles have capability to enhance the fiber optic sensing through amplifying fluorescence intensity and expect that their potential applications are used in a variety of biological applications.

Original languageEnglish
Title of host publication2010 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2010 - Proceedings
Pages574-578
Number of pages5
DOIs
StatePublished - 2010
Event2010 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2010 - Austin, TX, United States
Duration: 3 May 20106 May 2010

Publication series

Name2010 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2010 - Proceedings

Conference

Conference2010 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2010
Country/TerritoryUnited States
CityAustin, TX
Period3/05/106/05/10

Keywords

  • Biosensor
  • Fluorescence
  • Metalenhanced fluorescence
  • Nanoparticles

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