Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis

Yi Fang Yang, Chien Hsiu Li, Huei Yu Cai, Bo Syuan Lin, Cheorl Ho Kim*, Yu Chan Chang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Cellular metabolism governs the signaling that supports physiological mechanisms and homeostasis in an individual, including neuronal transmission, wound healing, and circadian clock manipulation. Various factors have been linked to abnormal metabolic reprogramming, including gene mutations, epigenetic modifications, altered protein epitopes, and their involvement in the development of disease, including cancer. The presence of multiple distinct hallmarks and the resulting cellular reprogramming process have gradually revealed that these metabolism-related molecules may be able to be used to track or prevent the progression of cancer. Consequently, translational medicines have been developed using metabolic substrates, precursors, and other products depending on their biochemical mechanism of action. It is important to note that these metabolic analogs can also be used for imaging and therapeutic purposes in addition to competing for metabolic functions. In particular, due to their isotopic labeling, these compounds may also be used to localize and visualize tumor cells after uptake. In this review, the current development status, applicability, and limitations of compounds targeting metabolic reprogramming are described, as well as the imaging platforms that are most suitable for each compound and the types of cancer to which they are most appropriate.

Original languageEnglish
Article number15831
JournalInternational Journal Of Molecular Sciences
Volume23
Issue number24
DOIs
StatePublished - Dec 2022

Keywords

  • cancer metabolism
  • cellular uptake
  • metabolic reprogramming
  • molecular imaging

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