Aortic regurgitation in Marfan syndrome patients who underwent prophylactic surgery: A single-center experience

Wen Po Fan, Hsing Yuan Li, Szu Yin Tseng, Chien Chang Juan, Betau Hwang, Dau Ming Niu, Pi Chang Lee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Marfan syndrome is an inherited connective tissue disease that causes aortic root dilatation and dissection and requires surgical intervention. Apart from emergent surgery for aortic dissection or aortic aneurysmal rupture, prophylactic surgical intervention can also be administered, depending on the severity of aortic root dilatation. The direct relationship between surgical intervention and aortic regurgitation was seldom mentioned in previous studies. Methods: A retrospective cohort study was designed to determine the clinical presentations of prophylactic surgery in patients with Marfan syndrome. Between January 2009 and May 2019, 112 patients, adolescents and young adults, treated in the Department of Pediatric Cardiology of Taipei Veterans General Hospital, were enrolled. All patients' sex, body measurements, echocardiography reports, and surgical notes were collected for statistical analysis. Results: Among the participants, nine patients (8%) underwent the Bentall procedure, and the other 103 did not receive surgical intervention. The operation group had a larger aortic root size (4.89 vs 2.86 cm, p < 0.001), more dilated left ventricle (4.81 vs 4.1 cm, p = 0.002), and higher prevalence of moderate and severe aortic regurgitation (66% vs 1%, p < 0.001) than the nonoperation group. Conclusion: Among adolescents and young adults with Marfan syndrome, echocardiographic presentation of aortic root dilatation, left ventricular dilatation, and significant aortic regurgitation was significantly associated with prophylactic surgical intervention. According to the study, significant aortic regurgitation should also be considered as an important indication for prophylactic surgery.

Original languageEnglish
Pages (from-to)540-544
Number of pages5
JournalJournal of the Chinese Medical Association
Issue number5
StatePublished - 1 May 2021


  • Aortic regurgitation
  • Blood vessel prosthesis implantation
  • Marfan syndrome


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