Antifungal Activities of Compounds Produced by Newly Isolated Acrocarpospora Strains

Ming Jen Cheng*, Jih Jung Chen, Ming Der Wu, Jyh Yih Leu, Min Tseng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


In our continued search for bioactive metabolites from cultures of rare Actinobacteria resources from all over Taiwan and various natural ecological environments, an active antimicrobial strain of Acrocarpospora punica 04107M was collected in Taitung County in Taiwan and prepared from soil. The bioassay-guided fractionation of the BuOH extract of a culture broth from A. punica 04107M led to the isolation of five previously undescribed compounds: Acrocarposporins A–E (Compounds 1–5). All the constituents were confirmed by HRESIMS and 1D- and 2D-NMR spectroscopy. Their antifungal activity was also evaluated. Our results showed that four constituents (Compounds 1, 2, 4, and 5) possessed mild antifungal activity against Aspergillus niger, Penicillium italicum, Candida albicans, and Saccharomyces cerevisiae. It is worth mentioning that the chemical composition of Acrocarpospora punica 04107M has never been studied. This is the first report on diterpenoid metabolites from the genus Acrocarpospora.

Original languageEnglish
Article number95
Issue number1
StatePublished - Jan 2023


  • Acrocarpospora punica 04107M
  • antifungal activities
  • diterpenoid
  • Streptosporangiaceae


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