Abstract
Aim: The extensive use of vancomycin has given rise to vancomycin-resistant bacterial strains, such as vancomycin-resistant Enterococci (VRE). We aim to explore potent medical treatments that can inhibit the growth of VRE. Materials & methods: Vancomycin-immobilized gold nanoparticles (Au@Van NPs) with polygonal shapes from one-pot reactions were generated within approximately 7 min. Results & discussion: The as-prepared Au NPs exhibit not only antibacterial capability but also photothermal competence. The temperature of the sample solution containing the as-prepared Au@Van NPs can be raised by approximately 15°C under irradiation by a near-infrared laser (λ = 808 nm) within 5 min. Conclusion: The required amount of vancomycin on the as-prepared Au@Van NPs combined with near-infrared irradiation for inhibiting VRE is approximately 16-fold lower than that of free-form vancomycin.
| Original language | English |
|---|---|
| Pages (from-to) | 1405-1416 |
| Number of pages | 12 |
| Journal | Nanomedicine |
| Volume | 13 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1 Jun 2018 |
Keywords
- antibacterial agents
- gold nanoparticles
- multivalent interactions
- near infrared (NIR)
- photothermal
- vancomycin
- vancomycin-resistant Enterococci