Anti-angiogenic therapy renders large tumors vulnerable to immunotherapy via reducing immunosuppression in the tumor microenvironment

Suit Fong Chan, Hao Tien Wang, Kai Wen Huang, Pao Ling Torng, Hsin I. Lee, Lih Hwa Hwang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We have recently demonstrated that a 4-in-1 gene therapy strategy that contains two anti-angiogenic genes [endostatin and pigment epithelium-derived factor] and two cytokine genes [granulocyte macrophage colony-stimulating factor and interleukin 12] has a considerable antitumor effect on large tumors in a woodchuck hepatoma model. The current study further investigates the underlying mechanisms for the antitumor effect observed by using small rodent models. We found that immunotherapy alone increased immunosuppressive cells in large tumors over time, whereas the anti-angiogenic therapy contained in the 4-in-1 strategy alleviated immunosuppression and made tumors vulnerable to immunotherapy, thus resulting in a synergistic antitumor effect.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalCancer Letters
Volume320
Issue number1
DOIs
StatePublished - 1 Jul 2012

Keywords

  • Adenovirus
  • Anti-angiogenesis
  • Gene therapy
  • Hepatocellular carcinoma
  • Immunotherapy

Fingerprint

Dive into the research topics of 'Anti-angiogenic therapy renders large tumors vulnerable to immunotherapy via reducing immunosuppression in the tumor microenvironment'. Together they form a unique fingerprint.

Cite this