Ankle-brachial index is a powerful predictor of renal outcome and cardiovascular events in patients with chronic kidney disease

Fu An Chen, Chih Yu Yang, Wu Chang Yang, Jinn Yang Chen, Yee Yung Ng, Szu Yuan Li, Wen Sheng Liu, Shiao Ti Cheng, Yu Jen Wang, Chih Ching Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Ankle-brachial index (ABI) is an accurate tool to diagnose peripheral arterial disease. The aim of this study was to evaluate whether ABI is also a good predictor of renal outcome and cardiovascular events in patients with chronic kidney disease (CKD). We enrolled 436 patients with stage 35CKD who had not been undergoing dialysis. Patients were stratified into two groups according to the ABI value with a cut point of 0.9. The composite renal outcome, including doubling of serum creatinine level and commencement of dialysis, and the incidence of cardiovascular events were compared between the two groups. After a median follow-up period of 13 months, the lower ABI group had a poorer composite renal outcome (OR = 2.719, P = 0.015) and a higher incidence of cardiovascular events (OR = 3.260, P = 0.001). Our findings illustrated that ABI is a powerful predictor of cardiovascular events and renal outcome in patients with CKD.

Original languageEnglish
Article number238494
JournalThe Scientific World Journal
Volume2012
DOIs
StatePublished - 2012

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