Angiopep-2-conjugated FeTi@Au core-shell nanoparticles for tumor targeted dual-mode magnetic resonance imaging and hyperthermic glioma therapy

Senthilkumar Thirumurugan; Pranjyan Dash; Xinrui Liu; Yuan Yun Tseng; Jui Hua Chung; Yunqian Li; Gang Zhao; Chingpo Lin; Yu Chien Lin; Ren Jei Chung

doi:10.1016/j.nano.2023.102673

Angiopep-2-conjugated FeTi@Au core-shell nanoparticles for tumor targeted dual-mode magnetic resonance imaging and hyperthermic glioma therapy

Senthilkumar Thirumurugan, Pranjyan Dash, Xinrui Liu, Yuan Yun Tseng, Jui Hua Chung, Yunqian Li, Gang Zhao, Chingpo Lin, Yu Chien Lin, Ren Jei Chung^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Herein, we fabricated gold surface-coated iron titanium core-shell (FeTi@Au) nanoparticles (NPs) with conjugation of angiopep-2 (ANG) (FeTi@Au-ANG) NPs for targeted delivery and improved NPs penetration by receptor-mediated endocytosis to achieve hyperthermic treatment of gliomas. The synthesized “core-shell” FeTi@Au-ANG NPs exhibited spherical in shape with around 16 nm particle size and increased temperature upon alternating magnetic field (AMF) stimulation, rendering them effective for localized hyperthermic therapy of cancer cells. Effective targeted delivery of FeTi@Au-ANG NPs was demonstrated in vitro by improved transport and cellular uptake, and increased apoptosis in glioma cells (C6) compared with normal fibroblast cells (L929). FeTi@Au-ANG NPs exhibited higher deposition in brain tissues and a superior therapeutic effect in an orthotopic intracranial xenograft mouse model. Taken together, our data indicate that FeTi@Au-ANG NPs hold significant promise as a targeted delivery strategy for glioma treatment using hyperthermia.

Original language	English
Article number	102673
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	50
DOIs	https://doi.org/10.1016/j.nano.2023.102673
State	Published - Jun 2023

Keywords

Angiopep-2
Blood-brain barrier
Glioma
Hyperthermia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.nano.2023.102673

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Thirumurugan, S., Dash, P., Liu, X., Tseng, Y. Y., Chung, J. H., Li, Y., Zhao, G., Lin, C., Lin, Y. C., & Chung, R. J. (2023). Angiopep-2-conjugated FeTi@Au core-shell nanoparticles for tumor targeted dual-mode magnetic resonance imaging and hyperthermic glioma therapy. Nanomedicine: Nanotechnology, Biology, and Medicine, 50, Article 102673. https://doi.org/10.1016/j.nano.2023.102673

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title = "Angiopep-2-conjugated FeTi@Au core-shell nanoparticles for tumor targeted dual-mode magnetic resonance imaging and hyperthermic glioma therapy",

abstract = "Herein, we fabricated gold surface-coated iron titanium core-shell (FeTi@Au) nanoparticles (NPs) with conjugation of angiopep-2 (ANG) (FeTi@Au-ANG) NPs for targeted delivery and improved NPs penetration by receptor-mediated endocytosis to achieve hyperthermic treatment of gliomas. The synthesized “core-shell” FeTi@Au-ANG NPs exhibited spherical in shape with around 16 nm particle size and increased temperature upon alternating magnetic field (AMF) stimulation, rendering them effective for localized hyperthermic therapy of cancer cells. Effective targeted delivery of FeTi@Au-ANG NPs was demonstrated in vitro by improved transport and cellular uptake, and increased apoptosis in glioma cells (C6) compared with normal fibroblast cells (L929). FeTi@Au-ANG NPs exhibited higher deposition in brain tissues and a superior therapeutic effect in an orthotopic intracranial xenograft mouse model. Taken together, our data indicate that FeTi@Au-ANG NPs hold significant promise as a targeted delivery strategy for glioma treatment using hyperthermia.",

keywords = "Angiopep-2, Blood-brain barrier, Glioma, Hyperthermia",

author = "Senthilkumar Thirumurugan and Pranjyan Dash and Xinrui Liu and Tseng, {Yuan Yun} and Chung, {Jui Hua} and Yunqian Li and Gang Zhao and Chingpo Lin and Lin, {Yu Chien} and Chung, {Ren Jei}",

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year = "2023",

month = jun,

doi = "10.1016/j.nano.2023.102673",

language = "English",

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AU - Thirumurugan, Senthilkumar

AU - Dash, Pranjyan

AU - Liu, Xinrui

AU - Tseng, Yuan Yun

AU - Chung, Jui Hua

AU - Li, Yunqian

AU - Zhao, Gang

AU - Lin, Chingpo

AU - Lin, Yu Chien

AU - Chung, Ren Jei

PY - 2023/6

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N2 - Herein, we fabricated gold surface-coated iron titanium core-shell (FeTi@Au) nanoparticles (NPs) with conjugation of angiopep-2 (ANG) (FeTi@Au-ANG) NPs for targeted delivery and improved NPs penetration by receptor-mediated endocytosis to achieve hyperthermic treatment of gliomas. The synthesized “core-shell” FeTi@Au-ANG NPs exhibited spherical in shape with around 16 nm particle size and increased temperature upon alternating magnetic field (AMF) stimulation, rendering them effective for localized hyperthermic therapy of cancer cells. Effective targeted delivery of FeTi@Au-ANG NPs was demonstrated in vitro by improved transport and cellular uptake, and increased apoptosis in glioma cells (C6) compared with normal fibroblast cells (L929). FeTi@Au-ANG NPs exhibited higher deposition in brain tissues and a superior therapeutic effect in an orthotopic intracranial xenograft mouse model. Taken together, our data indicate that FeTi@Au-ANG NPs hold significant promise as a targeted delivery strategy for glioma treatment using hyperthermia.

AB - Herein, we fabricated gold surface-coated iron titanium core-shell (FeTi@Au) nanoparticles (NPs) with conjugation of angiopep-2 (ANG) (FeTi@Au-ANG) NPs for targeted delivery and improved NPs penetration by receptor-mediated endocytosis to achieve hyperthermic treatment of gliomas. The synthesized “core-shell” FeTi@Au-ANG NPs exhibited spherical in shape with around 16 nm particle size and increased temperature upon alternating magnetic field (AMF) stimulation, rendering them effective for localized hyperthermic therapy of cancer cells. Effective targeted delivery of FeTi@Au-ANG NPs was demonstrated in vitro by improved transport and cellular uptake, and increased apoptosis in glioma cells (C6) compared with normal fibroblast cells (L929). FeTi@Au-ANG NPs exhibited higher deposition in brain tissues and a superior therapeutic effect in an orthotopic intracranial xenograft mouse model. Taken together, our data indicate that FeTi@Au-ANG NPs hold significant promise as a targeted delivery strategy for glioma treatment using hyperthermia.

KW - Angiopep-2

KW - Blood-brain barrier

KW - Glioma

KW - Hyperthermia

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JO - Nanomedicine: Nanotechnology, Biology, and Medicine

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Angiopep-2-conjugated FeTi@Au core-shell nanoparticles for tumor targeted dual-mode magnetic resonance imaging and hyperthermic glioma therapy

Abstract

Keywords

UN SDGs

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