Ancient Chinese medicine and mechanistic evidence of acupuncture physiology

Edward S. Yang*, Pei-Wen Li, Bernd Nilius, Geng Li

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    57 Scopus citations

    Abstract

    Acupuncture has been widely used in China for three millennia as an art of healing. Yet, its physiology is not yet understood. The current interest in acupuncture started in 1971. Soon afterward, extensive research led to the concept of neural signaling with possible involvement of opioid peptides, glutamate, adenosine and identifying responsive parts in the central nervous system. In the last decade scientists began investigating the subject with anatomical and molecular imaging. It was found that mechanical movements of the needle, ignored in the past, appear to be central to the method and intracellular calcium ions may play a pivotal role. In this review, we trace the technique of clinical treatment from the first written record about 2,200 years ago to the modern time. The ancient texts have been used to introduce the concepts of yin, yang, qi, de qi, and meridians, the traditional foundation of acupuncture. We explore the sequence of the physiological process, from the turning of the needle, the mechanical wave activation of calcium ion channel to beta-endorphin secretion. By using modern terminology to re-interpret the ancient texts, we have found that the 2nd century b.c. physiologists were meticulous investigators and their explanation fits well with the mechanistic model derived from magnetic resonance imaging (MRI) and confocal microscopy. In conclusion, the ancient model appears to have withstood the test of time surprisingly well confirming the popular axiom that the old wine is better than the new.

    Original languageEnglish
    Pages (from-to)645-653
    Number of pages9
    JournalPflugers Archiv European Journal of Physiology
    Volume462
    Issue number5
    DOIs
    StatePublished - 1 Nov 2011

    Keywords

    • Acoustic wave
    • Acupuncture
    • Ca ion channels
    • Calcium waves
    • Chinese traditional medicine
    • Meridians

    Fingerprint

    Dive into the research topics of 'Ancient Chinese medicine and mechanistic evidence of acupuncture physiology'. Together they form a unique fingerprint.

    Cite this