An umbrella review on the association between factors of oral health and cognitive dysfunction

Chia Shu Lin*, Ta Chung Chen, Merel Charlotte Verhoeff, Frank Lobbezoo, Mats Trulsson, Jong Ling Fuh

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


An increasing number of systematic reviews and meta-analyses have been published on the association between oral health and cognitive dysfunction, also known as oral-cognitive links. However, there is great diversity in the oral and cognitive factors included in these studies, with different opinions for clinical practice drawn from the evidence. To understand which oral and cognitive factors are involved in those associations, we conducted an umbrella review of 28 systematic reviews, including 12 meta-analyses, on oral-cognitive links. We found that (a) periodontal diseases, oral microbiome, and dementia were frequently studied, while other factors, such as mastication and mild cognitive impairment, were less commonly investigated, and (b) severe deterioration of oral health, such as severe periodontitis or extensive tooth loss, rather than the presence of oral diseases alone, was strongly associated with cognitive dysfunction. In conclusion, the diversity of oral and cognitive factors included in the review studies reflects the complexity of oral-cognitive links. Clarifying the factors helps to form evidence-based clinical advice for healthcare.

Original languageEnglish
Article number102128
JournalAgeing Research Reviews
StatePublished - Jan 2024


  • Aging
  • Dementia
  • Meta-analysis
  • Oral health
  • Periodontal diseases
  • Systematic review


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