An extended family of Fc receptor relatives

Randall S. Davis, Goetz R.A. Ehrhardt, Chuen Miin Leu, Masayuki Hirano, Max D. Cooper*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

59 Scopus citations


A surprising number of Fc receptor (FcR) relatives have been recognized recently with the potential capacity to modulate innate and adaptive immune responses. The six human FcR homologs (FcRH1-6), which belong to a phylogenetically conserved gene family, have variable numbers of extracellular immunoglobulin domains of five different subtypes. FcRH immunoregulatory potential is implicated by the presence of consensus tyrosine-based activation or inhibition motifs in their cytoplasmic tails. All but one of these new receptors, FcRH6, are expressed on B cells at different stages in differentiation. Their ligands, function, and prospective roles as diagnostic B cell markers and therapeutic targets are topics of intense interest.

Original languageEnglish
Pages (from-to)674-680
Number of pages7
JournalEuropean Journal of Immunology
Issue number3
StatePublished - Mar 2005


  • B cells
  • Fc receptor homologs
  • Fc receptors
  • Immunoreceptor tyrosine-based motifs
  • Malignancy


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