An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application

Feng Pai Chou; Chia Tse Tsai; Ya Sheng Chiou; Yi Ju Chen; Meng Erh Li; Ting Wei Guo; Jason Wen Jay Lyu; Sheng Hao Chou; Tung-Kung Wu

doi:10.1111/cbdd.12830

An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application

Feng Pai Chou
, Chia Tse Tsai
, Ya Sheng Chiou
, Yi Ju Chen
, Meng Erh Li
, Ting Wei Guo
, Jason Wen Jay Lyu
, Sheng Hao Chou
, Tung-Kung Wu^*

^*Corresponding author for this work

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.

Original language	English
Pages (from-to)	61-66
Number of pages	6
Journal	Chemical Biology and Drug Design
Volume	89
Issue number	1
DOIs	https://doi.org/10.1111/cbdd.12830
State	Published - 1 Jan 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

glycosyltransferase
Helicobacter pylori
MCF-7 breast cancer cell
steroid α-glucoside
sterol

Access to Document

10.1111/cbdd.12830

Cite this

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title = "An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application",

abstract = "Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.",

keywords = "glycosyltransferase, Helicobacter pylori, MCF-7 breast cancer cell, steroid α-glucoside, sterol",

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AU - Chou, Feng Pai

AU - Tsai, Chia Tse

AU - Chiou, Ya Sheng

AU - Chen, Yi Ju

AU - Li, Meng Erh

AU - Guo, Ting Wei

AU - Lyu, Jason Wen Jay

AU - Chou, Sheng Hao

AU - Wu, Tung-Kung

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AB - Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.

KW - glycosyltransferase

KW - Helicobacter pylori

KW - MCF-7 breast cancer cell

KW - steroid α-glucoside

KW - sterol

UR - https://www.scopus.com/pages/publications/84988447872

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JF - Chemical Biology and Drug Design

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