An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application

Feng Pai Chou; Chia Tse Tsai; Ya Sheng Chiou; Yi Ju Chen; Meng Erh Li; Ting Wei Guo; Jason Wen Jay Lyu; Sheng Hao Chou; Tung-Kung Wu

doi:10.1111/cbdd.12830

An enzymatic approach to configurationally rare trans-androsteronyl-α-glucoside and Its potential anticancer application

Feng Pai Chou, Chia Tse Tsai, Ya Sheng Chiou, Yi Ju Chen, Meng Erh Li, Ting Wei Guo, Jason Wen Jay Lyu, Sheng Hao Chou, Tung-Kung Wu^*

^*Corresponding author for this work

Department of Biological Science and Technology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.

Original language	English
Pages (from-to)	61-66
Number of pages	6
Journal	Chemical Biology and Drug Design
Volume	89
Issue number	1
DOIs	https://doi.org/10.1111/cbdd.12830
State	Published - 1 Jan 2017

Keywords

glycosyltransferase
Helicobacter pylori
MCF-7 breast cancer cell
steroid α-glucoside
sterol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/cbdd.12830

Cite this

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abstract = "Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.",

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AU - Chou, Feng Pai

AU - Tsai, Chia Tse

AU - Chiou, Ya Sheng

AU - Chen, Yi Ju

AU - Li, Meng Erh

AU - Guo, Ting Wei

AU - Lyu, Jason Wen Jay

AU - Chou, Sheng Hao

AU - Wu, Tung-Kung

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KW - Helicobacter pylori

KW - MCF-7 breast cancer cell

KW - steroid α-glucoside

KW - sterol

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