An autosomal genome-wide scan for loci linked to fre-diabetic phenotypes in nondiabetic Chinese subjects from the stanford asia-pacific program of hypertension and insulin resistance family Study

Yen Feng Chiu, Lee Ming Chuang, Chin Fu Hsiao, Yi Jen Hung, Ming Wei Lin, Ying Tsung Chen, John Grove, Eric Jorgenson, Thomas Quertermous, Neil Risch, Chao A. Hsiung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Type 2 diabetes is a complex disease involving both genetic and environmental components. Abnormalities in insulin secretion and insulin action usually precede the development of type 2 diabetes and can serve as good quantitative measures for genetic mapping. We therefore undertook an autosomal genomic search to locate the quantitative trait locus (QTL) linked to these traits in 1,365 nondiabetic Chinese subjects from 411 nuclear families. Residuals of these log-transformed quantitative traits were analyzed in multipoint linkage analysis using a variance-components approach. The most significant QTL for fasting insulin, which coincides with the QTL for homeostasis model assessment of insulin resistance, was located at 37 cM on chromosome 20, with a maximum empirical logarithm of odds (LOD) score of 3.01 (empirical P = 0.00006) when adjusted for age, sex, BMI, antihypertensive medications, recruitment centers, and environmental factors. In the same region, a QTL for fasting glucose was identified at 51 cM, with an empirical LOD score of 2.03 (empirical P = 0.0012). There were other loci with maximum empirical LOD scores ≥1.29 located on chromosomes 1q, 2p, 5q, 7p, 9q, 10p, 14q, 18q, and 19q for different diabetes-related traits. These loci may harbor genes that regulate glucose homeostasis either independently or via interactions of the genes within these regions.

Original languageEnglish
Pages (from-to)1200-1206
Number of pages7
JournalDiabetes
Volume54
Issue number4
DOIs
StatePublished - Apr 2005

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